Haematopoiesis & Immunity in Drosophila
DR CNRS 05 61 55 82 90
DR CNRS 05 61 55 68 23
- Benoit Augé-Duboé
- Caroline Monod
Associate professor Technical staff
- Vanessa Gobert
- Marc Haenlin
- Cedric Polesello
- Michelle Crozatier-Borde
- Nathalie Vanzo
- Amelie Destenabes
- Julien Favier
- Xiaohui Liu
- Alexia Rivero
- Linna Sheng
We have a long-standing interest in understanding hematopoiesis using Drosophila melanogaster as a model system. By combining multidisciplinary and integrated approaches encompassing Development, Genetics, Cell Biology and Molecular Biology, we aim at elucidating how blood cell development/formation is orchestrated and modulated under normal and pathological situations. Particularly, we aim at understanding how homeostatic blood cell production is regulated under normal conditions and in response to an immune stress. This includes determining how blood cell fates are specified, which mechanisms control the blood cell progenitor population maintenance versus defferentiation, the dialogues between micro-environment/niche cells and these progenitors, and how an emergency hematopoiesis is induced in response to parasite infestations in order to develop an adapted cellular immune response.
Keywords : Hematopoiesis, microenvironment/niche, lymph gland, stem-progenitor cells, blood cells, cardiac/vascular cells, Drosophila, signaling pathways, regulatory networks, cell plasticity.
- Tian Y, Morin-Poulard I, Liu X, Vanzo N, Crozatier M..
A mechanosensitive vascular niche for Drosophila hematopoiesis.
Proc Natl Acad Sci U S A
- Douaa Moussalem, Benoit Augé, Luisa Di Stefano, Dani Osman, Vanessa Gobert and Marc Haenlin1.
Two Isoforms of serpent Containing Either One or Two GATA Zinc Fingers Provide Functional Diversity During Drosophila Development
Frontiers in Cell and Developmental Biology
- Morin-Poulard* I., Destalminil-Letourneau M., Bataille L., Frendo J.L., Lebreton G., Vanzo N. and Michèle Crozatier* .
Identification of bi-potential blood cell/nephrocyte progenitors in Drosophila: another route for generating blood progenitors.
Front. Cell Dev. Biol.,
- Morin-Poulard I, Tian Y, Vanzo N, Crozatier M..
Drosophila as a Model to Study Cellular Communication Between the Hematopoietic Niche and Blood Progenitors Under Homeostatic Conditions and in Response to an Immune Stress.
Front Immunol Aug 16;12:719349. doi: 10.3389/fimmu.2021.719349.
- Destalminil-Letourneau M, Morin-Poulard I, Tian Y, Vanzo N, Crozatier M.
The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling
2021 Jan 4;10:e64672. doi: 10.7554/eLife.64672. PMID: 33395389
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