Haematopoiesis & Immunity in Drosophila
Michelle Crozatier-borde
Marc Haenlin

DR CNRS
05 61 55 82 90
DR CNRS
05 61 55 68 23
Team members
Researcher- Vanessa Gobert
- Marc Haenlin
- Fernando Roch
- Michelle Crozatier-borde
- Laurence Dubois
- Jean-louis Frendo
- Nathalie Vanzo
- Alain Vincent
- Francois Chassagne
Associate professor Technical staff- Benoit Augé-duboé
- Yannick Carrier
- Amelie Destenabes
- Julien Favier
- Caroline Monod
- Aurore Pelletier
Postdoctoral fellow PhD student- Xiaohui Liu
- Douaa Moussalem
- Delhia Gigan
- Yushun Tian
Master student- Kylia Hautchamp
- Leonie Gargouil
Presentation
We have a long-standing interest in understanding hematopoiesis using Drosophila melanogaster as a model system. By combining multidisciplinary and integrated approaches encompassing Development, Genetics, Cell Biology and Molecular Biology, we aim at elucidating how blood cell development/formation is orchestrated and modulated under normal and pathological situations. Particularly, we aim at understanding how homeostatic blood cell production is regulated under normal conditions and in response to an immune stress. This includes determining how blood cell fates are specified, which mechanisms control the blood cell progenitor population maintenance versus defferentiation, the dialogues between micro-environment/niche cells and these progenitors, and how an emergency hematopoiesis is induced in response to parasite infestations in order to develop an adapted cellular immune response.
Keywords : Hematopoiesis, microenvironment/niche, lymph gland, stem-progenitor cells, blood cells, cardiac/vascular cells, Drosophila, signaling pathways, regulatory networks, cell plasticity.

Publications
- Destalminil-Letourneau M, Morin-Poulard I, Tian Y, Vanzo N, Crozatier M.
The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling
Elife
2021 Jan 4;10:e64672. doi: 10.7554/eLife.64672. PMID: 33395389 - Alexandre Carayon, Laetitia Bataillé, Gaëlle Lebreton, Laurence Dubois, Aurore Pelletier, Yannick Carrier, Antoine Wystrach, Alain Vincent, Jean-Louis Frendo.
Intrinsic control of muscle attachment sites matching
eLife
2020 Jul 2020 Jul 24;9:e57547 - Laetitia Bataillé, Nathalie Colombié, Aurore Pelletier, Achim Paululat, Gaëlle Lebreton, Yannick Carrier, Jean-Louis Frendo, Alain Vincent.
Alary Muscles and Thoracic Alary-Related Muscles Are Atypical Striated Muscles Involved in Maintaining the Position of Internal Organs
Development
2020 May 2020 147: dev185645 doi: 10.1242/dev.185645 - Isabelle Louradour, Anurag Sharma, Ismael Mrin-Poulard, Manon Letourneau, Alain Vincent, Michèle Crozatier, Nathalie Vanzo .
Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism
eLIFE 6:e25496
2017 Nov - Tempesta C, Hijazi A, Moussian B, Roch F..
Boudin trafficking reveals the dynamic internalisation of specific septate junction components in Drosophila.
PLoS One.
2017 Oct
View all publications
Funding