Haematopoiesis & Immunity in Drosophila

Presentation

We have a long-standing interest in understanding hematopoiesis using Drosophila melanogaster as a model system. By combining multidisciplinary and integrated approaches encompassing Development, Genetics, Cell Biology and Molecular Biology, we aim at elucidating how blood cell development/formation is orchestrated and modulated under normal and pathological situations. Particularly, we aim at understanding how homeostatic blood cell production is regulated under normal conditions and in response to an immune stress. This includes determining how blood cell fates are specified, which mechanisms control the blood cell progenitor population maintenance versus defferentiation, the dialogues between micro-environment/niche cells and these progenitors, and how an emergency hematopoiesis is induced in response to parasite infestations in order to develop an adapted cellular immune response.

Keywords : Hematopoiesis, microenvironment/niche, lymph gland, stem-progenitor cells, blood cells, cardiac/vascular cells, Drosophila, signaling pathways, regulatory networks, cell plasticity.

Publications

• Destalminil-Letourneau M, Morin-Poulard I, Tian Y, Vanzo N, Crozatier M.
  The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling
  Elife
  2021 Jan 4;10:e64672. doi: 10.7554/eLife.64672. PMID: 33395389
• Alexandre Carayon, Laetitia Bataillé, Gaëlle Lebreton, Laurence Dubois, Aurore Pelletier, Yannick Carrier, Antoine Wystrach, Alain Vincent, Jean-Louis Frendo.
  Intrinsic control of muscle attachment sites matching
  eLife
  2020 Jul 2020 Jul 24;9:e57547
• Laetitia Bataillé, Nathalie Colombié, Aurore Pelletier, Achim Paululat, Gaëlle Lebreton, Yannick Carrier, Jean-Louis Frendo, Alain Vincent.
  Alary Muscles and Thoracic Alary-Related Muscles Are Atypical Striated Muscles Involved in Maintaining the Position of Internal Organs
  Development
  2020 May 2020 147: dev185645 doi: 10.1242/dev.185645
• Isabelle Louradour, Anurag Sharma, Ismael Mrin-Poulard, Manon Letourneau, Alain Vincent, Michèle Crozatier, Nathalie Vanzo .
  Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism
  eLIFE 6:e25496
  2017 Nov
• Tempesta C, Hijazi A, Moussian B, Roch F..
  Boudin trafficking reveals the dynamic internalisation of specific septate junction components in Drosophila.
  PLoS One.
  2017 Oct

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Funding