Cardiovascular homeostasis and regeneration

Presentation

The cardiovascular system is a vital network that ensures the maintenance of organs and tissues by providing oxygen, nutrients and a number of important circulating factors.

We are interested in understanding the mechanisms by which cells and molecules maintain homeostasis, contribute to disease or promote regeneration in cardiovascular tissues.

Using zebrafish as a model system, we combine genetics, single-cell and live-imaging approaches to unravel how the same element can wield either a pro-regenerative or a pro-disease role within different contexts.

Projets

Publications

• Cardeira-da-Silva, J.* #, Bensimon-Brito, A.*, Tarasco, M., Brandão, A. S., Rosa, J., Almeida, P. J., Jacinto, A., Cancela, M. L., Gavaia, P. J., Stainier, D. Y. R., Laizé, V..
  Fin ray branching is defined by TRAP+ osteolytic tubules
  PNAS 119(48) e2209231119
  2022 Oct
• Bensimon-Brito, A.*#, Boezio, G.L.M.*, Cardeira-da-Silva, J., Wietelmann, A., Helker, C.S.M., Ramadass, R., Piesker, J., Nauerth, A., Mueller, C., Stainier, D.Y.R..
  Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish
  Cardiovascular Research 118(12):2665-2687
  2022 Aug
• Gunawan, F.*#, Gentile, A.*, Gauvrit, S., Stainier, D. Y. R. #, Bensimon-Brito, A.*#.
  Nfatc1 promotes interstitial cell formation during cardiac valve development in zebrafish.
  Circulation Research 126:968–984
  2020 Feb
• Bensimon-Brito, A.#, Ramkumar*, S., Boezio*, G. L. M., Guenther, S., Kuenne, C., Helker, C. S. M., Sánchez-Iranzo, H., Iloska, D., Piesker, J., Pullamsetti, S., Mercader, N., Beis, D., Stainier, D. Y. R.#.
  TGF-ß signaling promotes tissue formation during cardiac valve regeneration in adult zebrafish.
  Developmental Cell 52(1):9-20
  2020 Jan
• Bensimon-Brito, A.* #, Cardeira, J.*, Dionísio. G., Huyesseune, A., Cancela, M.L., Witten, P.E..
  Revisiting in vivo staining with alizarin red S – a valuable approach to analyse zebrafish skeletal mineralization during development and regeneration
  BMC Developmental Biology 16(1):2
  2016 Jan

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Funding