Imprinted small non-coding RNAs

Presentation

Our research focuses on hundreds small noncoding RNAs belonging to the microRNA and C/D snoRNA families. These genes map to chromosomal regions regulated by genomic imprinting, an epigenetic phenomenon by which a few genes are mono-allelically expressed in a parent-of-origin specific manner. The rationale of our research is to explore the impact of recently evolved, imprinted small RNA genes on the evolution, expression and function of mammalian genomes, including in pathological contexts such as the Prader-Willi syndrome.

Projets

Publications

• Thalalla Gamage S*, Bortolin-Cavaillé ML*, Link C, Bryson K, Sas-Chen A, Schwartz S, Cavaillé J, Meier JL.
  Antisense pairing and SNORD13 structure guide RNA cytidine acetylation
  RNA
  2022 Sep rna.079254.122. doi: 10.1261/rna.079254.122. Online ahead of print. PMID: 3612712
• Marty V, Butler J, Basile C, Chargui O, Chagraoui A, Guiard BP, De Deurwaerdère P, Cavaillé J.
  Deleting Snord115 genes in mice remodels monoaminergic systems activity in the brain toward cortico-subcortical imbalances
  Hum Mol Genet
  2022 Aug 2022;ddac139. doi:10.1093/hmg/ddac139 Online ahead of print. PMID: 35951020
• Kobayashi N, Okae H, Hiura H, Kubota N, Kobayashi EH, Shibata S, Oike A, Hori T, Kikutake C, Hamada H, Kaji H, Suyama M, Bortolin-Cavaillé ML, Cavaillé J, Arima T..
  The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells.
  Nat Commun.
  2022 Jun 13(1):3071. doi: 10.1038/s41467-022-30775-w. PMID: 35654791 Free PMC article.
• Bortolin-Cavaillé ML, Aurélie Q, Supuni TG, Thomas JM, Sas-Chen A, Sharma S, Plisson-Chastang C, Vandel L, Blader P, Lafontaine DLJ, Schwartz S, Meier JL, Cavaillé J..
  Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution
  Nucleic Acids Res.
  2022 Jun 1:gkac404. doi: 10.1093/nar/gkac404. Online ahead of print. PMID: 35648437
• Hebras J, Marty V, Personnaz J, Mercier P, Krogh N, Nielsen H, Aguirrebengoa M, Seitz H, Pradere JP, Guiard BP, Cavaille J.
  Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model
  Elife. 2020 Oct 5;9:e60862
  2020 Oct doi: 10.7554/eLife.60862. PMID: 33016258 Free PMC article

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Funding

Fondation for Prader-Willi research

Ligue Régionale contre le Cancer