Imprinted small non-coding RNAs

Jérôme Cavaille


DR CNRS
05 61 33 59 34

Team members

  Research engineer
  • Marie-Line Bortolin
  • Virginie Marty
  Researcher
  • Jérôme Cavaille
  Associate professor
  • Patrice Vitali
  PhD student
  • Julie Riviere

Thèmes de recherche

    Presentation

    Our research focuses on hundreds small noncoding RNAs belonging to the microRNA and C/D snoRNA families. These genes map to chromosomal regions regulated by genomic imprinting, an epigenetic phenomenon by which a few genes are mono-allelically expressed in a parent-of-origin specific manner. The rationale of our research is to explore the impact of recently evolved, imprinted small RNA genes on the evolution, expression and function of mammalian genomes, including in pathological contexts such as the Prader-Willi syndrome.

    Projets

    Imprinted C/D snoRNA genes at the PWS locus

    Imprinted miRNA genes at the Dlk1-Dio3 locus

    Imprinted miRNA genes at the C19MC locus

    Publications

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    Funding

       

    Fondation for Prader-Willi research

    Ligue Régionale contre le Cancer

    Institute

    Université Paul Sabatier
    118 Route de Narbonne

    31062 TOULOUSE Cedex
    France

    Annuaire général