Imprinted small non-coding RNAs
Jérôme Cavaille

DR CNRS
05 61 33 59 34
Team members
Research engineer- Marie-Line Bortolin
- Virginie Marty
Researcher Associate professor PhD student
Presentation
Our research focuses on hundreds small noncoding RNAs belonging to the microRNA and C/D snoRNA families. These genes map to chromosomal regions regulated by genomic imprinting, an epigenetic phenomenon by which a few genes are mono-allelically expressed in a parent-of-origin specific manner. The rationale of our research is to explore the impact of recently evolved, imprinted small RNA genes on the evolution, expression and function of mammalian genomes, including in pathological contexts such as the Prader-Willi syndrome.
Projets
Imprinted C/D snoRNA genes at the PWS locus
Imprinted miRNA genes at the Dlk1-Dio3 locus
Imprinted miRNA genes at the C19MC locus
Publications
- Kobayashi N, Okae H, Hiura H, Kubota N, Kobayashi EH, Shibata S, Oike A, Hori T, Kikutake C, Hamada H, Kaji H, Suyama M, Bortolin-Cavaillé ML, Cavaillé J, Arima T..
The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells.
Nat Commun.
2022 Jun 13(1):3071. doi: 10.1038/s41467-022-30775-w. PMID: 35654791 Free PMC article. - Bortolin-Cavaillé ML, Aurélie Q, Supuni TG, Thomas JM, Sas-Chen A, Sharma S, Plisson-Chastang C, Vandel L, Blader P, Lafontaine DLJ, Schwartz S, Meier JL, Cavaillé J..
Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution
Nucleic Acids Res.
2022 Jun 1:gkac404. doi: 10.1093/nar/gkac404. Online ahead of print. PMID: 35648437 - Hebras J, Marty V, Personnaz J, Mercier P, Krogh N, Nielsen H, Aguirrebengoa M, Seitz H, Pradere JP, Guiard BP, Cavaille J.
Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model
Elife. 2020 Oct 5;9:e60862
2020 Oct doi: 10.7554/eLife.60862. PMID: 33016258 Free PMC article - Hebras J, Krogh N, Marty V, Nielsen H, Cavaillé J.
Developmental changes of rRNA ribose methylations in the mouse
RNA Biol. 2020 Jan;17(1):150-164
2020 Jan doi: 10.1080/15476286.2019.1670598. Epub 2019 Sep 29. PMID: 31566069 Free PMC article - Marty V., and Cavaillé J.
Imprinted small noncoding RNA genes in brain function and behaviour
Current Opinion in Behavioral Sciences. 25:8–14
2019 Jan
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Funding
Fondation for Prader-Willi research
Ligue Régionale contre le Cancer