Imprinted small non-coding RNAs

Presentation

Our research focuses on hundreds small noncoding RNAs belonging to the microRNA and C/D snoRNA families. These genes map to chromosomal regions regulated by genomic imprinting, an epigenetic phenomenon by which a few genes are mono-allelically expressed in a parent-of-origin specific manner. The rationale of our research is to explore the impact of recently evolved, imprinted small RNA genes on the evolution, expression and function of mammalian genomes, including in pathological contexts such as the Prader-Willi syndrome.

Projets

Publications

• Marty V., and Cavaillé J.
  Imprinted small noncoding RNA genes in brain function and behaviour
  Current Opinion in Behavioral Sciences. 25:8–14
  2019 Jan
• Hebras J. *, Krogh N.*, Marty V., Nielsen H. and Cavaillé J.
  Developmental changes of rRNA ribose methylations in the mouse
  RNA biol (in press)
  2019 Jan
• Malnou E.C., Umlauf D., Mouysset M., Cavaillé J.
  Imprinted MicroRNA Gene Clusters in the Evolution, Development, and Functions of Mammalian Placenta
  Front Genet. 18: 9:706
  2018 Jan
• Thomas JM, Briney CA, Nance KD, Lopez JE, Thorpe AL, Fox SD, Bortolin-Cavaille ML, Sas-Chen A, Arango D, Oberdoerffer S, Cavaille J, Andresson T, Meier JL.
  A Chemical Signature for Cytidine Acetylation in RNA
  J Am Chem Soc. 140:12667-12670
  2018 Jan
• Castel D, Baghdadi MB, Mella S, Gayraud-Morel B, Marty V, Cavaillé J, Antoniewski C, Tajbakhsh S.
  Small-RNA sequencing identifies dynamic microRNA deregulation during skeletal muscle lineage progression
  Sci Rep. 9; 8:4208. doi: 10.1038/s41598-018-21991
  2018 Jan

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Funding

Fondation for Prader-Willi research

Ligue Régionale contre le Cancer