Imprinted small non-coding RNAs

Jérôme Cavaille


DR CNRS
05 61 33 59 34

Team members

  Researcher
  • Jérôme Cavaille
  Technical staff
  • Marie-line Cavaille
  • Virginie Marty
  PhD student
  • Jade Hebras
  Master student
  • Celia Scribe
  • Celia Lecacheux

Presentation

Our research focuses on hundreds small noncoding RNAs belonging to the microRNA and C/D snoRNA families. These genes map to chromosomal regions regulated by genomic imprinting, an epigenetic phenomenon by which a few genes are mono-allelically expressed in a parent-of-origin specific manner. The rationale of our research is to explore the impact of recently evolved, imprinted small RNA genes on the evolution, expression and function of mammalian genomes, including in pathological contexts such as the Prader-Willi syndrome.

Projets

Imprinted C/D snoRNA genes at the PWS locus

Imprinted miRNA genes at the Dlk1-Dio3 locus

Imprinted miRNA genes at the C19MC locus

Publications

  • Marty V., and Cavaillé J.
    Imprinted small noncoding RNA genes in brain function and behaviour
    Current Opinion in Behavioral Sciences. 25:8–14
    2019 Jan
  • Hebras J. *, Krogh N.*, Marty V., Nielsen H. and Cavaillé J.
    Developmental changes of rRNA ribose methylations in the mouse
    RNA biol (in press)
    2019 Jan
  • Malnou E.C., Umlauf D., Mouysset M., Cavaillé J.
    Imprinted MicroRNA Gene Clusters in the Evolution, Development, and Functions of Mammalian Placenta
    Front Genet. 18: 9:706
    2018 Jan
  • Thomas JM, Briney CA, Nance KD, Lopez JE, Thorpe AL, Fox SD, Bortolin-Cavaille ML, Sas-Chen A, Arango D, Oberdoerffer S, Cavaille J, Andresson T, Meier JL.
    A Chemical Signature for Cytidine Acetylation in RNA
    J Am Chem Soc. 140:12667-12670
    2018 Jan
  • Castel D, Baghdadi MB, Mella S, Gayraud-Morel B, Marty V, Cavaillé J, Antoniewski C, Tajbakhsh S.
    Small-RNA sequencing identifies dynamic microRNA deregulation during skeletal muscle lineage progression
    Sci Rep. 9; 8:4208. doi: 10.1038/s41598-018-21991
    2018 Jan

View all publications

Funding

   

Fondation for Prader-Willi research

Ligue Régionale contre le Cancer

Institute

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

Annuaire général