Genome Dynamics: Stability, Transfer and Integration with the Cell-Cycle

François Cornet


DR CNRS
05 61 33 59 06

CR CNRS
05 61 33 59 84

Team members

  Researcher  Associate professor  Technical staff
  • Jérôme Rech
  • Luu Le phan thai
  • Carine Pagès
  • Patricia Siguier
  PhD student
  • Valentin Quebre
  • Hicham Sekkouri alaoui
  • Alix Meunier
  Master student
  • Camille Pin
  • Corentin Blanchais
  • Guillaume Morla
  --
  • Fanny Dornadic-potel

Presentation

Bacterial genomes are composed of a main chromosome and a plethora of diverse secondary replicons. These latter are the main drivers of genome plasticity by horizontal gene transfer, allowing bacterial adaptation, including acquisition of virulence and drugs multi-resistance.

Our group studies the maintenance functions of bacterial replicons in diverse bacterial species, their integration and their crosstalk with gene transfer and cell cycle dynamics. Combining molecular genetics, synthetic biology, biochemistry and fluorescence microscopy with bioinformatics and mathematical modeling, we are investigating the mechanisms and diversity of maintenance functions, the control of the cell-cycle and the control of gene transfer by conjugation and integration, including in the model gut microbiota of the worm C. elegans.

 

Projets

Diversity of ParABS systems

Mechanisms of Bacterial DNA segregation

Interplay between bacterial segregation and conjugation: StbAB

Genesis and maintenance of bacterial chromosomes

Internal control of the Xer recombination machine

Publications

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Funding

             

Institute

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

Annuaire général