Chromatin and Gene Expression

Kerstin Bystricky

05 61 55 67 31

Team members

  Research engineer
  • Edith Gourbeyre
  • Kerstin Bystricky
  • Anne-Claire Lavigne
  • Nicolas Tanguy Le Gac
  • Martin Rey-Millet
  Associate professor
  • David Umlauff
  Technical staff
  • Fatima Moutahir
  PhD student
  • Lea Costes


Do chromatin structure, chromosome motion and genome organization regulate nuclear processes? To address this question we investigate the functional relationship between the location of a gene, its inherent dynamics and its response to stimuli. We analyze epigenetic mechanisms of gene expression in mammary tumor cells, investigating in particular the role of histone variants and 3D folding of chromatin domains at estrogen receptor target genes. We develop techniques to visualize and image DNA in living cells, at the level of single loci and the whole genome, at high resolution, and methods to quantitatively analyze and model the data. Our challenge is experimentally acting upon structure to probe impact on function.


Chromatin dynamics and regulation of gene expression

Cancer chromatin signatures – role of histone variants

Chromosome dynamics and DNA repair


View all publications



Résultat de recherche d'images pour Kerstin BYSTRICKY, 2019 membre senior


Résultat de recherche d'images pour International 4D Nucleome action CA18127



Faculty/ Maitre de Conférences:
Silvia KOCANOVA, MCU depuis 2010, changement d'équipe 2022


Noémie KEMPF, postdoc 3/17-12/19
Hafida SELLOU, postdoc 4/17-4/18 now postdoc Lyon
Haitham SHABAN, postdoc 8/15-3/18 now postdoc EPFL, Switzerland
Franck GALLARDO, postdoc 06/10-12/13 now CEO NeoVirTech SA, Toulouse
Mathieu DALVAI, postdoc 10/08-12/12 now senior scientist to the Director, Quebec, Canada

PhD students:

Ludmila RECOULES, PhD 07/2021 (PhD student 10/17-06/21)
Sylvain AUDIBERT, PhD 11/2017 (PhD student 10/13-11/17, ATER 16-17, AI 01-03/18) now postdoc Bristol, UK
Barbara LAMBOUR, PhD 04/2016 (PhD student 02/14-04/16)
Hicham SAAD, PhD 11/2013 now at NIKON Canada
Luca BELLUCCI, PhD 03/2013 now teacher college Haute Garonne
Imen LASSADI, PhD 08/2012 now senior scientist Cambridge, UK
Mahta MAZAHERI, PhD 05/2009 now MD/PhD breast cancer institute, Iran
Laurence FLEURY, PhD 04/2008 now IE Région Albi

Ingénieurs and technical personnel:

Isabelle GOIFFON, AI/IE CNRS 10/17-08/20
Flavien RAYNAL, AI bioinfo CDD 10/18-12/19
Perrine UHART, AI CDD 05/18-08/19
Stéphanie CAZE-SUBRA, IE CDD 09/16-5/17 now IE
Sandrine KAPPLER-GRATIAS, IE CDD 06/14-3/17 now at NeoVirTech SA
Laurence FLEURY, IE CDD 06/12-04/13 now IE Région Albi

Master, Licence and BTS students:

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

05 61 33 58 00

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