Our team studies the molecular mechanisms involved in the adaptation processes of procaryotic genomes through comparative genomics and phylogenomics. We develop strategies to identify, reconstruct and classify, from the genomic sequences, functional supra-molecular assemblies and phylogenomics approaches, based on graph partitioning methods, to identify evolutionary relationships between genes/proteins and assemblies. We apply our approaches to conduct evolutionary analyses on diverse families of biological systems. In addition, we are also interested in the dynamics of the interaction between biological entities and focus, as sufficient experimental data are available, on the dynamic modeling of competence regulation during bacterial transformation in S. pneumoniae.
Manon Batista1, Petra Langendijk-Genevaux1, Mirna Hajj1,Duy Khanh Phung2, Laura Plassart3, Marie Bouvier1, Gwennaële Fichant1, and Béatrice Clouet-d’Orval1*. The Archaeal Specific Helicase of the Ski2-like family, ASH-Ski2, is an authentic RNA helicase 2019 Dec en préparation