Biology of the Centrosome

Andreas Merdes


DR CNRS
05 61 55 82 65

Team members

  Researcher
  • Thierry Gilbert
  • Laurence Haren
  • Andreas Merdes
  Associate professor
  • Christiane Bierkamp-Haenlin
  Technical staff
  • Julie Benedetti
  PhD student
  • Keying Guo
  --
  • Bastien Bayle

Thèmes de recherche

    Presentation

    Work in our group focuses on the proteins of the centrosome, and on their role in nucleation and organization of microtubules. We try to understand how microtubules are formed from the gamma-tubulin ring complex, a template structure consisting of gamma-tubulin and associated proteins. We investigate the protein interactions that trigger assembly and activation of this multi-protein complex. Because the centrosome loses its function as a microtubule-organizing centre in many differentiated cell types, and because centrosome proteins re-localize to novel sites of microtubule organization, we study the underlying mechanisms in two cellular models, myoblasts and skin keratinocytes. 

    Projets

    Ninein re-localizes from the centrosome to the cell cortex in differentiating skin keratinocytes

    The gamma-tubulin ring complex provides a template for microtubule nucleation

    Publications

    • Lecland N, Hsu CY, Chemin C, Merdes A, Bierkamp C.
      Epidermal development requires ninein for spindle orientation and cortical microtubule organization
      Life Sci Alliance
      2019 Mar 2:e201900373. doi: 10.26508/lsa.201900373.
    • Hsu CY, Lecland N, Pendaries V, Viodé C, Redoulès D, Paul C, Merdes A, Simon M, Bierkamp C..
      Stabilization of microtubules restores barrier function after cytokine-induced defects in reconstructed human epidermis.
      J Dermatol Sci. 2018 Jul;91(1):87-96.
      2018 Jul
    • Farache D, Emorine L, Haren L, Merdes A..
      Assembly and regulation of gamma-tubulin complexes.
      Open Biol. 2018 Mar;8(3). pii: 170266.
      2018 Mar
    • Lecland N, Merdes A. .
      Centriolar satellites prevent uncontrolled degradation of centrosome proteins: a speculative review
      Cell Stress, Vol. 2, No. 2, pp. 20 - 24
      2018 Feb
    • Cukier CD, Tourdes A, El-Mazouni D, Guillet V, Nomme J, Mourey L, Milon A, Merdes A, Gervais V..
      NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex.
      Protein Sci. 2017 Nov;26(11):2240-2248.
      2017 Nov

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    Institute

    Université Paul Sabatier
    118 Route de Narbonne

    31062 TOULOUSE Cedex
    France

    Annuaire général