Biology of the Centrosome

Andreas Merdes


DR CNRS
05 61 55 82 65

Team members

  Researcher
  • Thierry Gilbert
  • Laurence Haren
  • Andreas Merdes
  Associate professor
  • Christiane Bierkamp-Haenlin
  Technical staff
  • Julie Benedetti
  PhD student
  • Keying Guo
  • Camille Gorlt
  Master student
  • Eléonora Ledaki Engonopoulou

Presentation

Work in our group focuses on the proteins of the centrosome, and on their role in nucleation and organization of microtubules. We try to understand how microtubules are formed from the gamma-tubulin ring complex, a template structure consisting of gamma-tubulin and associated proteins. We investigate the protein interactions that trigger assembly and activation of this multi-protein complex. Because the centrosome loses its function as a microtubule-organizing centre in many differentiated cell types, and because centrosome proteins re-localize to novel sites of microtubule organization, we study the underlying mechanisms in two cellular models, myoblasts and skin keratinocytes. 

Projets

Ninein re-localizes from the centrosome to the cell cortex in differentiating skin keratinocytes

The gamma-tubulin ring complex provides a template for microtubule nucleation

Publications

  • Schweizer N, Haren L, Dutto I, Viais R, Lacasa C, Merdes A, Lüders J. .
    Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold.
    Nat Commun. 2021 Oct 15;12(1):6042. doi: 10.1038/s41467-021-26252-5.
    2021 Oct
  • Merdes A. .
    Microtubule nucleation without a ring?
    J Cell Biol. 2021 Mar 1;220(3):e202101015. doi: 10.1083/jcb.202101015.
    2021 Mar
  • Haren L, Farache D, Emorine L, Merdes A. .
    A stable sub-complex between GCP4, GCP5 and GCP6 promotes the assembly of γ-tubulin ring complexes.
    J Cell Sci. 2020 Jun 3;133(11):jcs244368. doi: 10.1242/jcs.244368.
    2020 Jun
  • Lecland N, Hsu CY, Chemin C, Merdes A, Bierkamp C.
    Epidermal development requires ninein for spindle orientation and cortical microtubule organization
    Life Sci Alliance
    2019 Mar 2:e201900373. doi: 10.26508/lsa.201900373.
  • Hsu CY, Lecland N, Pendaries V, Viodé C, Redoulès D, Paul C, Merdes A, Simon M, Bierkamp C..
    Stabilization of microtubules restores barrier function after cytokine-induced defects in reconstructed human epidermis.
    J Dermatol Sci. 2018 Jul;91(1):87-96.
    2018 Jul

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Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France


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