Coordinators : Magali Suzanne – Julie Batut
Animation : Magali Suzanne – Julie Batut – Denis Krndija
Cell cycle dynamics, regulation and timing at different scale
Our goal is:
Biomechanics: from cell to tissue
Our goal is:
The possibility to combine reversible inactivation of single genes with dynamic studies at single cell level in living samples will be instrumental to address the question of cell heterogeneity and to determine how an organism establishes and regulates this heterogeneity at a multiscale level.
Developmental disorders and diseases
Another important goal is to understand how cell dynamics and mechanics may become deregulated in disease, including developmental disorders and cancer by leading to aneuploidy and genetic instability.
Finally, we used integrative approaches, as shown by the increasing number of teams developing interdisciplinary approaches, such as biophysics, mathematical models, or bioinformatics analyses.
A versatile super-resolution microscope (RIM) allowing the visualization of macromolecule dynamics in whole tissues, overcoming the limitations of commercial super-resolution systems such as STORM, PALM and STED.
A non-invasive methods to measure forces (optical tweezers) allowing measurements of forces within a living tissue using an endogenous probe.
Microfluidic devices to study yeast division under physical constraint.
Laser microdissection with pulsed 532nm laser.
Optogenetics coupled to spinning disc microscope.