Mechanisms of chromatin patterning
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Research engineer Researcher Postdoctoral fellow PhD student
- Michela Anfossi
- Cheryn Ali
- Dominika Lewandowska
- Sanaa Bensaha
Inspired by the functional diversity among the genetically identical cells of an organism, our goal is to understand how cells can interpret their genome in a particular way to establish their cellular identity. To this end, we study the mechanisms that cells use to form and maintain cell type-specific chromatin patterns along their genome. As these patterns span multiple scales from a few modified histones to micron-sized subcompartments, we investigate them using complementary techniques from single-molecule biophysics to live-cell imaging and computational biology.
Genome-wide chromatin patterns
Epigenetic circuits in living cells
Single-molecule chromatin biophysics
- Dolde U, Muzzopappa F, Delesalle C, Neveu J, Erdel F, Vert G.
LEAFY homeostasis is regulated via ubiquitin-dependent degradation and sequestration in cytoplasmic condensates
iScience 26: 106880
- Erdel F.
Phase transitions in heterochromatin organization
Curr Opin Struct Biol 80: 102597
- Muzzopappa F, Hummert J, Anfossi M, Tashev SA, Herten DP, Erdel F.
Detecting and quantifying liquid-liquid phase separation in living cells by model-free calibrated half-bleaching
Nature Communications 13: 7787
- Muzzopappa F, Hertzog M, Erdel F..
DNA length tunes the fluidity of DNA-based condensates.
Biophys J 120: 1-13
- Erdel F.
Biophysical mechanisms of chromatin patterning
Curr Opin Genet Dev 61:62-68
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2019 - Elisabeth Schweigert (ERASMUS, Germany)
2020 - Antoine Solnais (M2 Genes, Cells & Development)
2021 - Andressa Arabe Alves (M1 Biotechnology)
2021 - Michela Anfossi (ERASMUS, Italy)