Mechanisms of chromatin patterning
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Technical staff PhD student
- Maud Hertzog
- Fabian Erdel
- Fernando Muzzopappa
- Cheryn Ali
- Dominika Lewandowska
- Andressa Arabe Alves
- Michela Anfossi
Inspired by the functional diversity among the genetically identical cells of an organism, our goal is to understand how cells can interpret their genome in a particular way to establish their cellular identity. To this end, we study the mechanisms that cells use to form and maintain cell type-specific chromatin patterns along their genome. As these patterns span multiple scales from a few modified histones to micron-sized subcompartments, we investigate them using complementary techniques from single-molecule biophysics to live-cell imaging and computational biology.
Genome-wide chromatin patterns
Epigenetic circuits in living cells
Single-molecule chromatin biophysics
- Muzzopappa F, Hertzog M, Erdel F..
DNA length tunes the fluidity of DNA-based condensates.
Biophys J 120: 1-13
- Erdel F.
Biophysical mechanisms of chromatin patterning
Curr Opin Genet Dev 61:62-68
- Erdel F, Rademacher A, Vlijm R, Tünnermann J, Frank L, Weinmann R, Schweigert E, Yserentant K, Hummert J, Bauer C, Schumacher S, Al Alwash A, Normand C, Herten DP, Engelhardt J, Rippe K.
Mouse heterochromatin adopts digital compaction states without showing hallmarks of HP1-driven liquid-liquid phase separation
Mol Cell 78:236–249
- Erdel F, Rippe K.
Formation of chromatin subcompartments by phase separation
Biophys J 114(10):2262-70
- Rademacher A, Erdel F, Trojanowski J, Schumacher S, Rippe K.
Real-time observation of light-controlled transcription in living cells
J Cell Sci 130(24):4213-24
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