Mechanisms of chromatin patterning
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Research engineer Researcher Postdoctoral fellow PhD student
- Cheryn Ali
- Dominika Lewandowska
- Sanaa Bensaha
- Michela Anfossi
- Laura Glepin
- Bastien Diaz
- Gaelle Lescalet
Inspired by the functional diversity among the genetically identical cells of an organism, our goal is to understand how cells can interpret their genome in a particular way to establish their cellular identity. To this end, we study the mechanisms that cells use to form and maintain cell type-specific chromatin patterns along their genome. As these patterns span multiple scales from a few modified histones to micron-sized subcompartments, we investigate them using complementary techniques from single-molecule biophysics to live-cell imaging and computational biology.
Genome-wide chromatin patterns
Epigenetic circuits in living cells
Single-molecule chromatin biophysics
- Muzzopappa F, Hummert J, Anfossi M, Tashev SA, Herten DP, Erdel F.
Detecting and quantifying liquid-liquid phase separation in living cells by model-free calibrated half-bleaching
Nature Communications 13: 7787
- Muzzopappa F, Hertzog M, Erdel F..
DNA length tunes the fluidity of DNA-based condensates.
Biophys J 120: 1-13
- Erdel F.
Biophysical mechanisms of chromatin patterning
Curr Opin Genet Dev 61:62-68
- Erdel F, Rademacher A, Vlijm R, Tünnermann J, Frank L, Weinmann R, Schweigert E, Yserentant K, Hummert J, Bauer C, Schumacher S, Al Alwash A, Normand C, Herten DP, Engelhardt J, Rippe K.
Mouse heterochromatin adopts digital compaction states without showing hallmarks of HP1-driven liquid-liquid phase separation
Mol Cell 78:236–249
- Erdel F, Rippe K.
Formation of chromatin subcompartments by phase separation
Biophys J 114(10):2262-70
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2019 - Elisabeth Schweigert (ERASMUS, Germany)
2020 - Antoine Solnais (M2 Genes, Cells & Development)
2021 - Andressa Arabe Alves (M1 Biotechnology)
2021 - Michela Anfossi (ERASMUS, Italy)