Mechanisms of chromatin patterning
Fabian Erdel
CR CNRS
05 61 33 58 60
Team members
Research engineer Researcher Postdoctoral fellow PhD student- Michela Anfossi
- Cheryn Ali
- Dominika Lewandowska
- Sanaa Bensaha
Master student
Presentation

Inspired by the functional diversity among the genetically identical cells of an organism, our goal is to understand how cells can interpret their genome in a particular way to establish their cellular identity. To this end, we study the mechanisms that cells use to form and maintain cell type-specific chromatin patterns along their genome. As these patterns span multiple scales from a few modified histones to micron-sized subcompartments, we investigate them using complementary techniques from single-molecule biophysics to live-cell imaging and computational biology.
Projets
Genome-wide chromatin patterns
Epigenetic circuits in living cells
Single-molecule chromatin biophysics
Publications
- Dolde U, Muzzopappa F, Delesalle C, Neveu J, Erdel F, Vert G.
LEAFY homeostasis is regulated via ubiquitin-dependent degradation and sequestration in cytoplasmic condensates
iScience 26: 106880
2023 May - Erdel F.
Phase transitions in heterochromatin organization
Curr Opin Struct Biol 80: 102597
2023 Apr - Muzzopappa F, Hummert J, Anfossi M, Tashev SA, Herten DP, Erdel F.
Detecting and quantifying liquid-liquid phase separation in living cells by model-free calibrated half-bleaching
Nature Communications 13: 7787
2022 Dec - Muzzopappa F, Hertzog M, Erdel F..
DNA length tunes the fluidity of DNA-based condensates.
Biophys J 120: 1-13
2021 Feb - Erdel F.
Biophysical mechanisms of chromatin patterning
Curr Opin Genet Dev 61:62-68
2020 May
View all publications
Funding
Alumni
Master students:
2019 - Elisabeth Schweigert (ERASMUS, Germany)
2020 - Antoine Solnais (M2 Genes, Cells & Development)
2021 - Andressa Arabe Alves (M1 Biotechnology)
2021 - Michela Anfossi (ERASMUS, Italy)