Mechanisms of chromatin patterning

Presentation

Inspired by the functional diversity among the genetically identical cells of an organism, our goal is to understand how cells can interpret their genome in a particular way to establish their cellular identity. To this end, we study the mechanisms that cells use to form and maintain cell type-specific chromatin patterns along their genome. As these patterns span multiple scales from a few modified histones to micron-sized subcompartments, we investigate them using complementary techniques from single-molecule biophysics to live-cell imaging and computational biology.

Projets

Publications

• Dolde U, Muzzopappa F, Delesalle C, Neveu J, Erdel F, Vert G.
  LEAFY homeostasis is regulated via ubiquitin-dependent degradation and sequestration in cytoplasmic condensates
  iScience 26: 106880
  2023 May
• Erdel F.
  Phase transitions in heterochromatin organization
  Curr Opin Struct Biol 80: 102597
  2023 Apr
• Muzzopappa F, Hummert J, Anfossi M, Tashev SA, Herten DP, Erdel F.
  Detecting and quantifying liquid-liquid phase separation in living cells by model-free calibrated half-bleaching
  Nature Communications 13: 7787
  2022 Dec
• Muzzopappa F, Hertzog M, Erdel F..
  DNA length tunes the fluidity of DNA-based condensates.
  Biophys J 120: 1-13
  2021 Feb
• Erdel F.
  Biophysical mechanisms of chromatin patterning
  Curr Opin Genet Dev 61:62-68
  2020 May

View all publications

Funding

Alumni

Master students:

2019 - Elisabeth Schweigert (ERASMUS, Germany)

2020 - Antoine Solnais (M2 Genes, Cells & Development)

2021 - Andressa Arabe Alves (M1 Biotechnology)

2021 - Michela Anfossi (ERASMUS, Italy)