Mechanisms of chromatin patterning
Fabian Erdel
DR CNRS
05 61 33 58 60
Team members
Research engineer- Christophe Normand
- Inga Tijunelyte
Researcher Postdoctoral fellow- Fernando Muzzopappa
- Cristina Silva
PhD student- Michela Anfossi
- Cheryn Ali
- Dominika Lewandowska
- Sanaa Bensaha
Presentation
Inspired by the functional diversity among the genetically identical cells of an organism, our goal is to understand how cells can interpret their genome in a particular way to establish their cellular identity. To this end, we study the mechanisms that cells use to form and maintain cell type-specific chromatin patterns along their genome. As these patterns span multiple scales from a few modified histones to micron-sized subcompartments, we investigate them using complementary techniques from single-molecule biophysics to live-cell imaging and computational biology.
Projets
Genome-wide chromatin patterns
Epigenetic circuits in living cells
Single-molecule chromatin biophysics
Publications
- Arnould C, Rocher V, Saur F, Bader AS, Muzzopappa F, Collins S, Lesage E, Le Bozec B, Puget N, Clouaire T, Mangeat T, Mourad R, Ahituv N, Noordermeer D, Erdel F, Bushell M, Marnef A, Legube G..
Chromatin compartmentalization regulates the response to DNA damage
Nature
2023 Oct - Dolde U, Muzzopappa F, Delesalle C, Neveu J, Erdel F, Vert G.
LEAFY homeostasis is regulated via ubiquitin-dependent degradation and sequestration in cytoplasmic condensates
iScience 26: 106880
2023 May - Erdel F.
Phase transitions in heterochromatin organization
Curr Opin Struct Biol 80: 102597
2023 Apr - Muzzopappa F, Hummert J, Anfossi M, Tashev SA, Herten DP, Erdel F.
Detecting and quantifying liquid-liquid phase separation in living cells by model-free calibrated half-bleaching
Nature Communications 13: 7787
2022 Dec - Muzzopappa F, Hertzog M, Erdel F..
DNA length tunes the fluidity of DNA-based condensates.
Biophys J 120: 1-13
2021 Feb
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Funding
Alumni
Master students:
2019 - Elisabeth Schweigert (ERASMUS, Germany)
2020 - Antoine Solnais (Master Genes, Cells & Development)
2021 - Andressa Arabe Alves (Master Biotechnology)
2023 - Gaëlle Lescalet (Master Structural Biology & Genomics)
2023 - Laura Glepin (Master Biology & Health)
Bachelor students:
2023 - Sarah Mialet (Bachelor Biology)