Cell Dynamics - EMT and Directional Cell Migration

Eric Theveneau


CR CNRS
05 61 55 60 26

Team members

  Researcher
  • Cathy Danesin
  • Eric Theveneau
  Associate professor
  • Bruno Glise
  Technical staff
  • Sandrine Paute
  • Marie Rey
  Postdoctoral fellow
  • évangéline Despin-Guitard
  Master student
  • John Goll

Presentation

Our lab focuses on mechanisms of cell dynamics: epithelial-mesenchymal transition, directional cell migration, cell polarity and tissue mechanics. We aim at understanding basic principles that rule cell movements in complex environments during embryogenesis and cancer. We use embryos as tools to better understand the function of key players in cancer progression and muscular diseases such as the extracellular matrix, metalloproteinases and guidance cues.

We use two experimental models: chicken embryo (neural crest, mesoderm) and the xenopus embryo (neural crest). Neural Crest and mesoderm development rely on several oncogenes (snail, twist, ets...)
and their overall behaviour recapitulates the main steps of tumour metastasis in a controlled, reproducible manner, facilitating experimental approaches. Mesoderm development allows us to study repeated rounds of EMT and MET in a single cell type.

Our goal is to use our findings on experimental models to better understand cell dynamics defects occurring in diseases (cancer, inflammation).

 

If you are interested in working on cell migration and EMT in a multidisciplinary environment, we are always looking for post-doc and PhD applicants.

Informal enquiries can be sent directly to Eric Theveneau at - eric.theveneau[at]univ-tlse3.fr

Follow me on X (Twitter) @EricTheveneau

 

 

Projets

Functions of Metalloproteinases during EMT an cell migration

Cell dynamics and tissue mechanics during epithelial-mesenchymal transition

Neural crest EMT and migration

Publications

View all publications

Funding

                 

Alumni

Lea Roquin - Master Student 2023

Anne Bibonne - T CNRS 2014-2022 (mobilité > Nantes)

Wilke Meijer - Master Student 2021

Li Xue-Nan - Master Student (China) 2020

Fraha Haidar - Master Student 2019

Olivia Vantroeyen - Master Student 2018

Nadège Gouignard - Post-doc 2016-2018

Fernanda Bajanca - Post-doc 2015-2019

Cyril Andrieu - PhD Student 2014-2018

Audrey Montigny - Engineer 2013-2015

Fernando Duarte - Technician/PhD Student 2014-2017

Matthieu Brunet - Undergrad. 2015.

Anna B. Berki - Undergrad. 2015.

Elena Scarpa - EMBO short-term visiting PhD student (University College London), 2014.

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France


05 61 33 58 00

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