Molecular Chaperone Networks
Pierre Genevaux
CR CNRS
05 61 33 58 73
Team members
Researcher- Patricia Bordes
- Pierre Genevaux
Associate professor- Marie-Pierre Castanié-Cornet
Technical staff- Anne-Marie Cirinesi
- Michèle Coddeville
Postdoctoral fellow PhD student
Presentation

The Molecular Chaperone Networks research group at the Laboratory of Microbiology and Molecular genetics (LMGM-CBI) mainly focuses on the biology of molecular chaperone machines in bacteria. Genetics, molecular biology and biochemistry technics are used to identify new molecular chaperone functions and to pin point key interplay between major chaperones, such as DnaK/HSP70, DnaJ/HSP40, GroEL/HSP60, Trigger Factor or SecB, and other bacterial stress proteins, including Toxin-Antitoxin systems (see Figure). More recently, we have focused on SecB-like molecular chaperones in the human pathogen M. tuberculosis and revealed for the first time the control of a stress-responsive Toxin-Antitoxin system by molecular chaperones.
Publications
- Texier P, Bordes P, Nagpal J, Sala AJ, Mansour M, Cirinesi AM, Xu X, Dougan DA, Genevaux P.
ClpXP-mediated Degradation of the TAC Antitoxin is Neutralized by the SecB-like Chaperone in Mycobacterium tuberculosis
J Mol Biol. 433(5):166815. doi: 10.1016/j.jmb.2021.166815
2021 Jan Online ahead of print. PMID: 33450247 - Yiming Cai, Ben Usher, Claude Gutierrez, Anastasia Tolcan, Moise Mansour, Peter C. Fineran, Ciarán Condon, Olivier Neyrolles, Pierre Genevaux, Tim R. Blower.
A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems
Science Advances
2020 Jul Vol. 6, no. 31, eabb6651 DOI: 10.1126/sciadv.abb6651 - Barriot R, Latour J, Castanié-Cornet MP, Fichant G, Genevaux P.
J-Domain Proteins in Bacteria and Their Viruses
J Mol Biol.
2020 Apr S0022-2836(20)30301-6. doi:10.1016/j.jmb.2020.04.014 - Ayala S, Genevaux P, Hureau C, Faller P.
(Bio)chemical Strategies To Modulate Amyloid-β Self-Assembly
ACS Chem. Neurosci
2019 Aug 10(8):3366-3374. doi:10.1021/acschemneuro.9b00239 - Akarsu H, Mansour M, Bordes P, Bigot DJ, Genevaux P, Falquet L.
TASmania: a bacterial Toxin-Antitoxin Systems database
PLoS Computational Biology
2019 Apr
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Funding
Alumni
Moïse Mansour
Olivier Fayet
Marie-Françoise Prère
Donna Joe Bigot
Sarah Ayala
Ola Al-fawares
Pauline Texier
Nawel Slama
Ambre Sala
Frédéric Angles
Nicolas Bruel
Elsa Perrody