REMEMBeR : Revealing Memory Mechanisms of the Brain

Presentation

Our research addresses the fundamental question of how enduring memories are formed in the brain. We are studying more specifically mechanisms of cerebral plasticity related to spatial and episodic memory in normal mice and in mouse models of memory dysfunctions or pathologies (Alzheimer’s disease, mood disorders, post-traumatic stress disorder). Our work focuses on learning-induced plasticity processes at different levels from the activity of neuronal networks (cerebral oscillations, synaptic plasticity, inhibitory networks), to cells (neurogenesis, morphology of neurons or glial cells, interactions between neurons and glia), neurobiological issues (protein or gene expression, release of neurotransmitters, role of mitochondria) to finally work at the molecular level (epigenetic regulations, role of transcriptional factors).

• Twitter: @RememberCrca

Our team is a member of:

• French Neuroscience Society: https://www.neurosciences.asso.fr/

• GDR Memory: https://gdrmemoire.com/
• Network of Centers of Excellence in Neurodegeneration (COEN): https://www.coen.org/
• Institut Carnot Cognition: http://www.institut-cognition.com/

 

 

 

Media:

• CNRS-INSB press release on Rey et al. 2022: https://www.insb.cnrs.fr/fr/cnrsinfo/remanier-lhippocampe-permet-aux-souris-alzheimer-de-retrouver-la-memoire-des-autres
• "Les secrets de la mémoire" Essentiel Radio – Interview with L  Verret, 2022: https://www.essentielradio.com/podcasts/les-secrets-de-la-memoire-podcast-11-05-1311 
• "Comment fonctionne notre mémoire ?" SIMPLE, Konbini News – L Verret, 2022: https://news.konbini.com/societe/video-la-memoire-comment-ca-fonctionne/ 
• Social memory in adolescence:  https://www.neurosciences.asso.fr/2020/01/comment-la-memoire-sociale-emerge-a-ladolescence

 

 

 

Projets

Lab news

Hippocampus dysfunction and Alzheimer’s Disease

Metabolic and Neuropsychiayric disorders: role of hippocampe plasticity

Neuropeptides and memory

Adult neurogenesis and memory

Synaptic plasticities induced by learning

Transcriptional control of memory consolidation

Publications

• Viguier C, Bullich S, Botella M, Fasseu L, Alfonso A, Rekik K, Gauzin S, Guiard BP, Davezac N.
  Impact of physical activity on brain oxidative metabolism and intrinsic capacities in young swiss mice fed a high fat diet
  Neuropharmacology. 2023 Dec 15;241:109730. doi: 10.1016/j.neuropharm.2023.109730
  2023 Dec
• Martin H, Coursan A, Lallement J, Di Miceli M, Kandiah J, Raho I, Buttler J, Guilloux JP, De Deurwaerdere P, Layé S, Routh VH, Guiard BP, Magnan C, Cruciani-Guglielmacci C, Fioramonti X.
  Serotonergic neurons are involved in the counter-regulatory response to hypoglycemia
  J Neuroendocrinol. 2023 Dec;35(12):e13344. doi: 10.1111/jne.13344
  2023 Dec
• D'Oliveira da Silva F, Robert C, Lardant E, Pizzano C, Bruchas MR, Guiard BP, Chauveau F, Moulédous L.
  Targeting Nociceptin/Orphanin FQ receptor to rescue cognitive symptoms in a mouse neuroendocrine model of chronic stress
  Mol Psychiatry. 2023 Dec 20. doi: 10.1038/s41380-023-02363-x
  2023 Dec
• Andraini T, Moulédous L, Petsophonsakul P, Florian C, Gauzin S, Botella-Daloyau M, Arrázola M, Nikolla K, Philip A, Leydier A, Marque M, Arnauné-Pelloquin L, Belenguer P, Rampon C, Miquel MC.
  Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice
  eNeuro. 2023 Nov 20;10(11):ENEURO.0073-23.2023
  2023 Nov
• D'Oliveira da Silva F, Zaveri NT, Moulédous L.
  Acute single non-sedative doses of NOP receptor agonists affect acquisition of object location memory but repeated high doses do not induce long-lasting deficits
  Neurobiol Learn Mem. 2023 Nov;205:107841. doi: 10.1016/j.nlm.2023.107841
  2023 Nov

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Funding

                   

 

 

Alumni

• Christophe REY (phD in 2020), currently product manager (VWR)
• Benjamin PORTAL (phD in 2018), currently postdoc at the Karolinska Institute, Sweden
• Vanessa CATTAUD (PhD in 2018), currently postdoc at the university of Alberta, Canada
• Trinovita ANDRAINI (PhD in 2017), currently associate professor at Medical University of Indonesia, Jakarta
• Khaoula REKIK (PhD in 2017), currently lecturer at the University of Toulouse Le Mirail
• Petnoi PETSOPHONSAKUL (PhD in 2017), currently employed by a private company in England
• Hélène VILLAIN (PhD in 2016), currently clinical research assistant in Paris
• Charlotte BEZZINA (PhD in 2015), currently in Psychology school in Toulouse, France
• Jessica REMAUD (PhD in 2014), currently "Responsable R&D " at AgreenCulture, France
• Kevin RICHETIN (PhD in 2014), currently postdoc at UNIL Lausanne, Switzerland
• Nicolas MASSALY (PhD in 2012), currently Assistant Professor in Anesthesiology, Washington University Pain Center, Saint Louis, MO
• Clémence LECLERC (PhD in 2012), currently employed by a private company
• Alice KREZYMON (PhD in 2012), currently teacher in Irvine, California, USA
• Timothé ESCUDE (PhD in 2012) currently Med School student in Toulouse, France
• Johnatan CECCOM (PhD in 2011), currently at School of Pharmacy in Toulouse, France
• Stéphanie TROUCHE (PhD in 2009) currently CNRS Researcher at IGF Montpellier, France
• Alexandre BETOURNE (PhD in 2008), currently Scientific Director at Critical Path Institute (C-Path), Tuscon, AZ