REMEMBeR : Revealing Memory Mechanisms of the Brain

Presentation

Our research addresses the fundamental question of how enduring memories are formed in the brain. We are studying more specifically mechanisms of cerebral plasticity related to spatial and episodic memory in normal mice and in mouse models of memory dysfunctions or pathologies (Alzheimer’s disease, mood disorders, post-traumatic stress disorder). Our work focuses on learning-induced plasticity processes at different levels from the activity of neuronal networks (cerebral oscillations, synaptic plasticity, inhibitory networks), to cells (neurogenesis, morphology of neurons or glial cells, interactions between neurons and glia), neurobiological issues (protein or gene expression, release of neurotransmitters, role of mitochondria) to finally work at the molecular level (epigenetic regulations, role of transcriptional factors).

• Twitter: @RememberCrca

Our team is a member of:

• French Neuroscience Society: https://www.neurosciences.asso.fr/

• GDR Memory: https://gdrmemoire.com/
• Network of Centers of Excellence in Neurodegeneration (COEN): https://www.coen.org/
• Institut Carnot Cognition: http://www.institut-cognition.com/

 

 

 

Media:

• CNRS-INSB press release on Rey et al. 2022: https://www.insb.cnrs.fr/fr/cnrsinfo/remanier-lhippocampe-permet-aux-souris-alzheimer-de-retrouver-la-memoire-des-autres
• "Les secrets de la mémoire" Essentiel Radio – Interview with L  Verret, 2022: https://www.essentielradio.com/podcasts/les-secrets-de-la-memoire-podcast-11-05-1311 
• "Comment fonctionne notre mémoire ?" SIMPLE, Konbini News – L Verret, 2022: https://news.konbini.com/societe/video-la-memoire-comment-ca-fonctionne/ 
• Social memory in adolescence:  https://www.neurosciences.asso.fr/2020/01/comment-la-memoire-sociale-emerge-a-ladolescence

 

 

 

Projets

Lab news

Hippocampus dysfunction and Alzheimer’s Disease

Metabolic and Neuropsychiayric disorders: role of hippocampe plasticity

Neuropeptides and memory

Adult neurogenesis and memory

Synaptic plasticities induced by learning

Transcriptional control of memory consolidation

Publications

• Bullich S, de Souto Barreto P, Dortignac A, He L, Dray C, Valet P, Guiard BP.
  Apelin controls emotional behavior in age- and metabolic state-dependent manner
  Psychoneuroendocrinology. 2022;140:105711. doi: 10.1016/j.psyneuen.2022.105711
  2022 Mar
• Rey CC, Robert V, Bouisset G, Loisy M, Lopez S, Cattaud V, Lejards C, Piskorowski RA, Rampon C, Chevaleyre V, Verret L.
  Altered inhibitory function in hippocampal CA2 contributes in social memory deficits in Alzheimer's mouse model
  iScience. 2022;25(3):103895. doi: 10.1016/j.isci.2022.103895
  2022 Feb
• Fulton S, Décarie-Spain L, Fioramonti X, Guiard B, Nakajima S.
  The menace of obesity to depression and anxiety prevalence
  Trends Endocrinol Metab. 2022;33(1):18-35. doi: 10.1016/j.tem.2021.10.005
  2022 Jan
• Pomeshchik Y, Klementieva O, Gil J, Martinsson I, Hansen MG, de Vries T, Sancho-Balsells A, Russ K, Savchenko E, Collin A, Vaz AR, Bagnoli S, Nacmias B, Rampon C, Sorbi S, Brites D, Marko-Varga G, Kokaia Z, Rezeli M, Gouras GK, Roybon L.
  Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies
  Stem Cell Reports. 2021;16(11):2838. doi: 10.1016/j.stemcr.2021.10.003
  2021 Nov
• Santin Y, Lopez S, Ader I, Andrieu S, Blanchard N, Carrière A, Casteilla L, Cousin B, Davezac N, De Souto Barreto P, Dray C, Fazilleau N, Gonzalez-Dunia D, Gourdy P, Guyonnet S, Jabrane-Ferrat N, Kunduzova O, Lezoualc'h F, Liblau R, Martinez LO, Moro C, Payoux P, Pénicaud L, Planat-Bénard V, Rampon C, Rolland Y, Schanstra JP, Sierra F, Valet P, Varin A, Vergnolle N, Vellas B, Viña J, Guiard BP, Parini A..
  Towards a Large-Scale Assessment of the Relationship between Biological and Chronological Aging: The INSPIRE Mouse Cohort.
  J Frailty Aging. 2021;10(2):121-131. doi: 10.14283/jfa.2020.43.
  2021 Oct

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Funding

                   

 

 

Alumni

• Christophe REY (phD in 2020), currently product manager (VWR)
• Benjamin PORTAL (phD in 2018), currently postdoc at the Karolinska Institute, Sweden
• Vanessa CATTAUD (PhD in 2018), currently postdoc at the university of Alberta, Canada
• Trinovita ANDRAINI (PhD in 2017), currently associate professor at Medical University of Indonesia, Jakarta
• Khaoula REKIK (PhD in 2017), currently lecturer at the University of Toulouse Le Mirail
• Petnoi PETSOPHONSAKUL (PhD in 2017), currently employed by a private company in England
• Hélène VILLAIN (PhD in 2016), currently clinical research assistant in Paris
• Charlotte BEZZINA (PhD in 2015), currently in Psychology school in Toulouse, France
• Jessica REMAUD (PhD in 2014), currently "Responsable R&D " at AgreenCulture, France
• Kevin RICHETIN (PhD in 2014), currently postdoc at UNIL Lausanne, Switzerland
• Nicolas MASSALY (PhD in 2012), currently Assistant Professor in Anesthesiology, Washington University Pain Center, Saint Louis, MO
• Clémence LECLERC (PhD in 2012), currently employed by a private company
• Alice KREZYMON (PhD in 2012), currently teacher in Irvine, California, USA
• Timothé ESCUDE (PhD in 2012) currently Med School student in Toulouse, France
• Johnatan CECCOM (PhD in 2011), currently at School of Pharmacy in Toulouse, France
• Stéphanie TROUCHE (PhD in 2009) currently CNRS Researcher at IGF Montpellier, France
• Alexandre BETOURNE (PhD in 2008), currently Scientific Director at Critical Path Institute (C-Path), Tuscon, AZ