REMEMBeR : Revealing Memory Mechanisms of the Brain

Presentation

Our research addresses the fundamental question of how enduring memories are formed in the brain. We are studying more specifically mechanisms of cerebral plasticity related to spatial and episodic memory in normal mice and in mouse models of memory dysfunctions or pathologies (Alzheimer’s disease, mood disorders, post-traumatic stress disorder). Our work focuses on learning-induced plasticity processes at different levels from the activity of neuronal networks (cerebral oscillations, synaptic plasticity, inhibitory networks), to cells (neurogenesis, morphology of neurons or glial cells, interactions between neurons and glia), neurobiological issues (protein or gene expression, release of neurotransmitters, role of mitochondria) to finally work at the molecular level (epigenetic regulations, role of transcriptional factors).

• Twitter: @RememberCrca

Our team is a member of:

• French Neuroscience Society: https://www.neurosciences.asso.fr/

• GDR Memory: https://gdrmemoire.com/
• Network of Centers of Excellence in Neurodegeneration (COEN): https://www.coen.org/
• Institut Carnot Cognition: http://www.institut-cognition.com/

 

 

 

Media:

• CNRS-INSB press release on Rey et al. 2022: https://www.insb.cnrs.fr/fr/cnrsinfo/remanier-lhippocampe-permet-aux-souris-alzheimer-de-retrouver-la-memoire-des-autres
• "Les secrets de la mémoire" Essentiel Radio – Interview with L  Verret, 2022: https://www.essentielradio.com/podcasts/les-secrets-de-la-memoire-podcast-11-05-1311 
• "Comment fonctionne notre mémoire ?" SIMPLE, Konbini News – L Verret, 2022: https://news.konbini.com/societe/video-la-memoire-comment-ca-fonctionne/ 
• Social memory in adolescence:  https://www.neurosciences.asso.fr/2020/01/comment-la-memoire-sociale-emerge-a-ladolescence

 

 

 

Projets

Lab news

Hippocampus dysfunction and Alzheimer’s Disease

Metabolic and Neuropsychiayric disorders: role of hippocampe plasticity

Neuropeptides and memory

Adult neurogenesis and memory

Synaptic plasticities induced by learning

Transcriptional control of memory consolidation

Publications

• Coutens B, Lejards C, Bouisset G, Verret L, Rampon C, Guiard BP.
  Enriched environmental exposure reduces the onset of action of the serotonin norepinephrin reuptake inhibitor venlafaxine through its effect on parvalbumin interneurons plasticity in mice
  Transl Psychiatry. 2023 Jun 26;13(1):227. doi: 10.1038/s41398-023-02519-x
  2023 Jun
• B Szabo A, Cattaud V, Bezzina C, Dard RF, Sayegh F, Gauzin S, Lejards C, Valton L, Rampon C, Verret L, Dahan L.
  Neuronal hyperexcitability in the Tg2576 mouse model of Alzheimer's disease - the influence of sleep and noradrenergic transmission
  Neurobiol Aging. 2023 Mar;123:35-48. doi: 10.1016/j.neurobiolaging.2022.11.017
  2023 Mar
• Jäntti H, Oksanen M, Kettunen P, Manta S, Mouledous L, Koivisto H, Ruuth J, Trontti K, Dhungana H, Keuters M, Weert I, Koskuvi M, Hovatta I, Linden AM, Rampon C, Malm T, Tanila H, Koistinaho J, Rolova T.
  Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
  Cells. 2022 Dec 18;11(24):4116. doi: 10.3390/cells11244116
  2022 Dec
• Martin H, Bullich S, Martinat M, Chataigner M, Di Miceli M, Simon V, Clark S, Butler J, Schell M, Chopra S, Chaouloff F, Kleinridders A, Cota D, De Deurwaerdere P, Pénicaud L, Layé S, Guiard BP, Fioramonti X.
  Insulin modulates emotional behavior through a serotonin-dependent mechanism
  Mol Psychiatry. 2022 Oct 7. doi: 10.1038/s41380-022-01812-3
  2022 Oct
• Portal B, Vasile F, Zapata J, Lejards C, Ait Tayeb AEK, Colle R, Verstuyft C, Corruble E, Rouach N, Guiard BP.
  Astroglial Connexins Inactivation Increases Relapse of Depressive-like Phenotype after Antidepressant Withdrawal
  Int J Mol Sci. 2022 Oct 30;23(21):13227. doi: 10.3390/ijms232113227
  2022 Oct

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Funding

                   

 

 

Alumni

• Christophe REY (phD in 2020), currently product manager (VWR)
• Benjamin PORTAL (phD in 2018), currently postdoc at the Karolinska Institute, Sweden
• Vanessa CATTAUD (PhD in 2018), currently postdoc at the university of Alberta, Canada
• Trinovita ANDRAINI (PhD in 2017), currently associate professor at Medical University of Indonesia, Jakarta
• Khaoula REKIK (PhD in 2017), currently lecturer at the University of Toulouse Le Mirail
• Petnoi PETSOPHONSAKUL (PhD in 2017), currently employed by a private company in England
• Hélène VILLAIN (PhD in 2016), currently clinical research assistant in Paris
• Charlotte BEZZINA (PhD in 2015), currently in Psychology school in Toulouse, France
• Jessica REMAUD (PhD in 2014), currently "Responsable R&D " at AgreenCulture, France
• Kevin RICHETIN (PhD in 2014), currently postdoc at UNIL Lausanne, Switzerland
• Nicolas MASSALY (PhD in 2012), currently Assistant Professor in Anesthesiology, Washington University Pain Center, Saint Louis, MO
• Clémence LECLERC (PhD in 2012), currently employed by a private company
• Alice KREZYMON (PhD in 2012), currently teacher in Irvine, California, USA
• Timothé ESCUDE (PhD in 2012) currently Med School student in Toulouse, France
• Johnatan CECCOM (PhD in 2011), currently at School of Pharmacy in Toulouse, France
• Stéphanie TROUCHE (PhD in 2009) currently CNRS Researcher at IGF Montpellier, France
• Alexandre BETOURNE (PhD in 2008), currently Scientific Director at Critical Path Institute (C-Path), Tuscon, AZ