REMEMBeR : Revealing Memory Mechanisms of the Brain

Presentation

Our research addresses the fundamental question of how enduring memories are formed in the brain. We are studying more specifically mechanisms of cerebral plasticity related to spatial and episodic memory in normal mice and in mouse models of memory dysfunctions or pathologies (Alzheimer’s disease, mood disorders, post-traumatic stress disorder). Our work focuses on learning-induced plasticity processes at different levels from the activity of neuronal networks (cerebral oscillations, synaptic plasticity, inhibitory networks), to cells (neurogenesis, morphology of neurons or glial cells, interactions between neurons and glia), neurobiological issues (protein or gene expression, release of neurotransmitters, role of mitochondria) to finally work at the molecular level (epigenetic regulations, role of transcriptional factors).

• Twitter: @RememberCrca

Our team is a member of:

• French Neuroscience Society: https://www.neurosciences.asso.fr/

• GDR Memory: https://gdrmemoire.com/
• Network of Centers of Excellence in Neurodegeneration (COEN): https://www.coen.org/
• Institut Carnot Cognition: http://www.institut-cognition.com/

 

 

 

Media:

Interview of Laure Verret for Radio France Alzheimer: https://radiofrancealzheimer.org/broadcast/12581-Les-souvenirs-sont-ils-perdus-%C3%A0-jamais

Social memory in adolescence:  https://www.neurosciences.asso.fr/2020/01/comment-la-memoire-sociale-emerge-a-ladolescence

 

 

 

Projets

Lab news

Hippocampus dysfunction and Alzheimer’s Disease

Metabolic and Neuropsychiayric disorders: role of hippocampe plasticity

Neuropeptides and memory

Adult neurogenesis and memory

Synaptic plasticities induced by learning

Transcriptional control of memory consolidation

Publications

• Bullich S, Delcourte S, Haddjeri N, Guiard BP.
  Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype
  Int J Mol Sci. 22(2):937. doi: 10.3390/ijms22020937
  2021 Jan PMID: 33477830 Free PMC article
• Dahan L, Rampon C, Florian C.
  Age-related Memory Decline, Dysfunction of the Hippocampus and Therapeutic Opportunities
  Prog Neuropsychopharmacol Biol Psychiatry. 2020;102:109943. doi: 10.1016/j.pnpbp.2020.109943.
  2020 Apr
• Bridi M, Schoch H, Florian C, Poplawski S.G, Banerjee A, Hawk JD, Porcari GS, Lejards C, Hahn CG, Giese KP, Havekes R, Spruston N, Abel T.
  Transcriptional Corepressor SIN3A Regulates Hippocampal Synaptic Plasticity via Homer1/mGluR5 Signaling
  JCI Insight. 2020;5(5):e92385. doi: 10.1172/jci.insight.92385.
  2020 Mar
• Minville V, Mouledous L, Jaafar A, Couture R, Brouchet A, Frances B, Tack I, Girolami JP.
  Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists.
  J Transl Med. 2019;17(1):346. doi: 10.1186/s12967-019-2095-9
  2019 Oct
• Domínguez S, Rey CC, Therreau L, Fanton A, Massotte D, Verret L, Piskorowski RA, Chevaleyre V.
  Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory.
  Cell Rep. 2019;29(5):1099-1112.e4. doi: 10.1016/j.celrep.2019.09.044
  2019 Oct

View all publications

Funding

                   

 

 

Alumni

• Vanessa CATTAUD (PhD in 2018), currently postdoc at the university of Alberta, Canada
• Trinovita ANDRAINI (PhD in 2017), currently associate professor at Medical University of Indonesia, Jakarta
• Khaoula REKIK (PhD in 2017), currently employed by a private company in Toulouse
• Petnoi PETSOPHONSAKUL (PhD in 2017), currently employed by a private company in England
• Hélène VILLAIN (PhD in 2016), currently clinical research assistant in Paris
• Charlotte BEZZINA (PhD in 2015), currently in Psychology school in Toulouse, France
• Jessica REMAUD (PhD in 2014), currently "Responsable R&D " at AgreenCulture, France
• Kevin RICHETIN (PhD in 2014), currently postdoc at UNIL Lausanne, Switzerland
• Nicolas MASSALY (PhD in 2012), currently postdoc at Washington University in St Louis, MI, USA
• Clémence LECLERC (PhD in 2012), currently employed by a private company
• Alice KREZYMON (PhD in 2012), currently teacher in Irvine, California, USA
• Timothé ESCUDE (PhD in 2012) currently Med School student in Toulouse, France
• Johnatan CECCOM (PhD in 2011), currently at School of Pharmacy in Toulouse, France
• Stéphanie TROUCHE (PhD in 2009) currently CNRS Researcher at IGF Montpellier, France
• Alexandre BETOURNE (PhD in 2008), currently Chief Medical Officer at Above and Beyond, Atlanta, GA, USA