Alzheimer's disease (AD) is the most common form of dementia in the elderly. This progressive neurodegenerative disease is characterized by inexorable loss of memory and other cognitive functions. Despite decades of research effort, the underlying mechanisms of memory loss during AD are still poorly understood. Using transgenic mouse models of AD, we are scrutinizing how the pathology affects hippocampal plasticity from network to cellular levels, with a particular emphasis on whether some plasticity is retaining despite AD. We are also testing new behavioral, pharmacological and optogenetic approaches aiming at ameliorating memory functions in AD mice.
More specifically, our ongoing projects focus on:
EU Joint Programme – Neurodegenerative Disease Research : http://www.cellmadgic.eu/