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Researcher Associate professor Technical staff Postdoctoral fellow
- Daniela Roellig
- Tatiana Merle
- Emmanuel Martin
- Marianne Montemurro
- Meritxell Font Noguera
- Sophie Theis
We are interested in the process of morphogenesis and seek to understand how organs acquire their specific shapes. We are more specifically interested in cell dynamics during fundamental cellular events such as cell death or cell delamination and seek to characterize their impact on epithelial layers remodeling. In addition to the biochemical signals that cells send to modulate the behavior of their neighbors, cells can also influence their environment mechanically. One of the key objectives of mechanobiology, a rapidly expanding field of research, is to understand how mechanical forces are generated, transmitted and integrated within a tissue.
We take as a study model the formation of folds, a simple morphogenetic process allowing to go from a 2-dimensional structure to a 3-dimensional structure. We use a combination of models: Drosophila, Chicken/quail and theoretical models.
Our work is at the interface of developmental biology, cell biology and biophysics.
Apoptosis dynamics in vertebrates
Dynamics of cell delamination
Apoptotic force generation and transmission
- Meritxell Font-Noguera, Marianne Montemurro, Corinne Benassayag, Bruno Monier, Magali Suzanne.
Getting started for migration: A focus on EMT cellular dynamics and mechanics in developmental models
Cells Dev .
- Sophie Theis, Magali Suzanne, and Guillaume Gay.
Tyssue: an epithelium simulation library
- Emmanuel Martin, Sophie Theis, Guillaume Gay, Bruno Monier, Christian Rouvière, Magali Suzanne .
Arp2/3-dependent mechanical control of morphogenetic robustness in an inherently challenging environment
- Emmanuel Martin, Magali Suzanne.
When the Community Silences Disruptive Elements: Multiscale Mechanical Coupling Buffers Morphogenetic Imprecisions
Dev Cell .
- Mélanie Gracia, Sophie Theis, Amsha Proag, Guillaume Gay, Corinne Benassayag and Magali Suzanne.
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
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__________________________________________________________________________ The team
__________________________________________________________________________ On going Collaborations
Guillaume Gay, Turing center Marseille
Mounia Lagha, IGM Montpellier
Guillaume Charras, MRC London
Mélanie Gettings (Post doc)
Sonia Schott (Engineer)
Marie-Anaïs Thibergien (PhD)
Arnaud Ambronisi (PhD)
Mélanie Gracia (PhD)
Mégane Rayer (PhD)
Amsha Proag (Post Doc)
Audrey Barbaste (Engineer)