DR 05 61 55 65 07
- Bruno Monier
- Magali Suzanne
Technical staff Postdoctoral fellow PhD student
- Corinne Benassayag
- Stephanie Arnould
- Meritxell Font Noguera
- Marianne Montemurro
- Ronan Bouzignac
We are interested in the process of morphogenesis and seek to understand how organs acquire their specific shapes. We are more specifically interested in cell dynamics during fundamental cellular events such as cell death or cell delamination and seek to characterize their impact on epithelial layers remodeling. In addition to the biochemical signals that cells send to modulate the behavior of their neighbors, cells can also influence their environment mechanically. One of the key objectives of mechanobiology, a rapidly expanding field of research, is to understand how mechanical forces are generated, transmitted and integrated within a tissue.
We take as a study model the formation of folds, a simple morphogenetic process allowing to go from a 2-dimensional structure to a 3-dimensional structure. We use a combination of models: Drosophila, Chicken/quail and theoretical models.
Our work is at the interface of developmental biology, cell biology and biophysics.
Cellular dynamics of tumor progression
Apoptosis dynamics in vertebrates
Dynamics of cell delamination
Apoptotic force generation and transmission
- Daniela Roellig, Sophie Theis, Amsha Proag, Guillaume Allio, Bertrand Bénazéraf, Jérôme Gros, Magali Suzanne.
Force-generating apoptotic cells orchestrate avian neural tube bending
- Bruno Monier, Magali Suzanne.
Orchestration of Force Generation and Nuclear Collapse in Apoptotic Cells
Inter J Mol Sci.
2021 Sep Review
- Meritxell Font-Noguera, Marianne Montemurro, Corinne Benassayag, Bruno Monier, Magali Suzanne.
Getting started for migration: A focus on EMT cellular dynamics and mechanics in developmental models
Cells Dev .
- Sophie Theis, Magali Suzanne, and Guillaume Gay.
Tyssue: an epithelium simulation library
- Emmanuel Martin, Sophie Theis, Guillaume Gay, Bruno Monier, Christian Rouvière, Magali Suzanne .
Arp2/3-dependent mechanical control of morphogenetic robustness in an inherently challenging environment
View all publications
__________________________________________________________________________ The team
__________________________________________________________________________ On going Collaborations
Guillaume Gay, Turing center Marseille
Mounia Lagha, IGM Montpellier
Guillaume Charras, MRC London