Apoptosis-dependent Morphogenesis

Magali Suzanne


DR
05 61 55 85 88

Team members

  Researcher
  • Bruno Monier
  Associate professor
  • Corinne Benassayag
  • Stephanie Arnould
  Technical staff
  • Martine Cazales
  Postdoctoral fellow
  • Emmanuel Martin
  • Daniela Roellig
  • Tatiana Merle
  PhD student
  • Sophie Theis
  • Meritxell Font Noguera
  • Marianne Montemurro
  Master student
  • Ugo Arles Bottega

Presentation

We are interested in the process of morphogenesis and seek to understand how organs acquire their specific shapes. We are more specifically interested in cell dynamics during fundamental cellular events such as cell death or cell delamination and seek to characterize their impact on epithelial layers remodeling. In addition to the biochemical signals that cells send to modulate the behavior of their neighbors, cells can also influence their environment mechanically. One of the key objectives of mechanobiology, a rapidly expanding field of research, is to understand how mechanical forces are generated, transmitted and integrated within a tissue.

We take as a study model the formation of folds, a simple morphogenetic process allowing to go from a 2-dimensional structure to a 3-dimensional structure. We use a combination of models: Drosophila, Chicken/quail and theoretical models.

Our work is at the interface of developmental biology, cell biology and biophysics.

 

Projets

Cellular dynamics of tumor progression

The team

Morphogenesis Robustness

Biophysical modeling

Tools

Apoptosis dynamics in vertebrates

Dynamics of cell delamination

Apoptotic force generation and transmission

Publications

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Funding

 

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__________________________________________________________________________     On going Collaborations                                                                                                            

Guillaume Gay, Turing center Marseille

Mounia Lagha, IGM Montpellier

Guillaume Charras, MRC London

Institute

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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