Apoptosis-dependent Morphogenesis

Presentation

We are interested in the process of morphogenesis and seek to understand how organs acquire their specific shapes. We are more specifically interested in cell dynamics during fundamental cellular events such as cell death or cell delamination and seek to characterize their impact on epithelial layers remodeling. In addition to the biochemical signals that cells send to modulate the behavior of their neighbors, cells can also influence their environment mechanically. One of the key objectives of mechanobiology, a rapidly expanding field of research, is to understand how mechanical forces are generated, transmitted and integrated within a tissue.

We take as a study model the formation of folds, a simple morphogenetic process allowing to go from a 2-dimensional structure to a 3-dimensional structure. We use a combination of models: Drosophila, Chicken/quail and theoretical models.

Our work is at the interface of developmental biology, cell biology and biophysics.

Projets

Publications

• Ben Meriem Z, Mateo T, Faccini J, Denais C, Dusfour-Castan R, Guynet C, Merle T, Suzanne M, Di-Luoffo M, Guillermet-Guibert J, Alric B, Landiech S, Malaquin L, Mesnilgrente F, Laborde A, Mazenq L, Courson R, Delarue M..
  A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding.
  Lab Chip. 10;23(20):4445-4455
  2023 Oct doi: 10.1039/d3lc00313b
• Merle T.* #, Theis S.*, Kamgoué A., Martin E., Sarron F., Gay G., Farge E. and Suzanne M#..
  DISSECT is a tool to segment and explore cell and tissue mechanics in highly deformed 3D epithelia
  Developmental Cell
  2023 Jul
• Schott S., Barbaste A., Benassayag C. and Suzanne M..
  Dissecting morphogenetic apoptosis through a genetic screen in Drosophila
  Life Science Alliance
  2023 Jul DOI: 10.26508/lsa.202301967
• Daniela Roellig, Sophie Theis, Amsha Proag, Guillaume Allio, Bertrand Bénazéraf, Jérôme Gros, Magali Suzanne.
  Force-generating apoptotic cells orchestrate avian neural tube bending
  Developmental Cell
  2022 Mar
• Bruno Monier, Magali Suzanne.
  Orchestration of Force Generation and Nuclear Collapse in Apoptotic Cells
  Inter J Mol Sci.
  2021 Sep Review

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Funding

__________________________________________________________________________     The team                                                                                                                                   

__________________________________________________________________________     On going Collaborations                                                                                                            

Guillaume Gay, Turing center Marseille

Mounia Lagha, IGM Montpellier

Guillaume Charras, MRC London