Small nuclear regulatory RNAs

Presentation

The nuclei of human cells contain an enormous number of small nuclear regulatory RNAs (snRNAs) which, in the forms of small nuclear ribonucleoproteins (snRNPs), function in all aspects of gene expression. Our research focuses on the understanding of the structural and functional complexity, the biogenesis and intracellular trafficking of human snRNPs. In the past, we have described and functionally characterized several novel groups of human snRNPs. Recently, we are dissecting the complex transcriptional regulatory function of the 7SK snRNP that controls RNA polymerase II activity. We also study the biogenesis and function of a novel class of snRNAs, the AluACA RNAs, which are processed from intronic Alu repetitive sequences.

Projets

Publications

• Yuan Yang, Shiheng Liu, Sylvain Egloff, Catherine D Eichhorn, Tanya Hadjian, James Zhen, Tamás Kiss, Z Hong Zhou, Juli Feigon.
  Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP
  Mol Cell .
  2022 Mar
• Jády BE, Ketele A, Moulis D, Kiss T..
  Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity.
  Genes Dev.
  2021 Dec
• Sylvain Egloff.
  CDK9 keeps RNA polymerase II on track
  Cell Mol Life Sci .
  2021 Jul
• Cécilia Studniarek, Michael Tellier, Pascal G P Martin, Shona Murphy, Tamás Kiss, Sylvain Egloff.
  The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming
  Cell Rep . 2021 Apr 13;35(2):108965. doi: 10.1016/j.celrep.2021.108965.
  2021 Apr
• Studniarek C, Egloff S, Murphy S.
  Noncoding RNAs Set the Stage for RNA Polymerase II Transcription
  Trends Genet. S0168-9525(20)30249-3. doi: 10.1016/j.tig.2020.09.013
  2020 Oct

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Funding