Team publications Kiss
Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP
Mol Cell .
Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity.
CDK9 keeps RNA polymerase II on track
Cell Mol Life Sci .
The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming
Cell Rep . 2021 Apr 13;35(2):108965. doi: 10.1016/j.celrep.2021.108965.
Noncoding RNAs Set the Stage for RNA Polymerase II Transcription
Trends Genet. S0168-9525(20)30249-3. doi: 10.1016/j.tig.2020.09.013
Cooperative 2'-O-methylation of the wobble cytidine of human elongator tRNAMet(CAT) by a nucleolar and a Cajal body-specific box C/D RNP.
Genes Dev. 2019 Jun 6. doi: 10.1101/gad.326363.119.
Dynamic association of human mRNP proteins with mitochondrial tRNAs in the cytosol.
7SK small nuclear RNA, a multifunctional transcriptional regulatory RNA with gene-specific features.
Transcription. 9: 95-101.
The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression.
EMBO J., 36, 934-948.
Human intron-encoded AluACA RNAs and telomerase RNA share a common element promoting RNA accumulation.
RNA Biol., 13, 1274-1285.
The pol II CTD: new twists in the tail.
Nat Struct Mol Biol., 23, 771-777.
Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.
Nucleic Acids Res., 44, 1342-53.
CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription.
Transcription, 6, 79-90.
Targeting of vertebrate intron-encoded box C/D 2’-O-methylation guide RNAs into the Cajal body.
Nucleic Acids Res., 42, 6616-6629.
Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.
Oncogene, 33, 474-483
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP.
Nucleic Acids Res., 41, 4686-4698.
Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H/ACA RNPs.
Genes & Dev., 26, 1897-1910.
Specific small nucleolar RNA expression profiles in acute leukemia.
Leukemia, 26, 2052-2060.
Role of Ser7 phosphorylation of the CTD during transcription of snRNA genes.
RNA Biol., 9, 1033-1038.
Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication.
Nucleic Acids Res., 40, 6270-6289.
Updating the RNA polymerase CTD code: adding gene-specific layers.
Trends Genet., 28, 333-341
Utp23p is required for dissociation of snR30 small nucleolar RNP from pre-ribosomal particles.
Nucleic Acids Res., 40, 3641-3652.
Misregulation of P-TEFb activity: pathological consequences.
Med Sci, 28, 200-205.
Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes.
Mol. Cell, 13, 111-122.
Controlling cellular P-TEFb activity by the HIV transcriptional transactivator Tat.
Plos Pathogens 6, e1001152.
Box H/ACA small ribonucleoproteins.
Mol. Cell, 37, 597-606.
18S rRNA processing requires base-pairings of snR30 H/ACA snoRNA to eukaryote-specific 18S sequences.
EMBO J., 28, 1260-1270.
Human U1 snRNA forms a new chromatin-associated snRNP with TAF15.
EMBO Rep., 10, 494-500.
The HSP90 chaperone controls the biogenesis of L7Ae RNPs through a conserved machinery.
J. Cell Biol., 180, 579-595.
Structural and functional characterization of human telomerase RNA processing and Cajal body localization signals.
Mol. Cell, 27, 869-881.
Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb.
EMBO J., 26, 3570-3580.
SnoRNP biogenesis meets pre-mRNA splicing.
Mol. Cell 23, 775-776.
Integrating snoRNP assembly with mRNA biogenesis.
EMBO Rep., 7, 590-592.
Cotranscriptional recognition of human box H/ACA snoRNAs occurs in a splicing-independent manner.
Mol. Cell. Biol., 26, 2540-2549.
Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres.
Mol. Biol. Cell, 17, 944-954.
Regulation of polymerase II transcription by 7SK snRNA: Two distinct RNA elements direct P-TEFb and HEXIM1 binding.
Mol. Cell. Biol., 26, 630-642.
Biogenesis and intranuclear trafficking of human box C/D and H/ACA RNPs.
Cold Spring Harbor Symposia on Quantitative Biology.
Biogenesis of small nuclear RNPs.
J. Cell. Science, 117, 5949-5951.
PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli.
Mol. Cell, 16, 777-787.
Human box H/ACA pseudouridylation guide RNA machinery.
Mol. Cell. Biol., 24, 5797-5807.
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal.
J. Cell Biol., 164, 647-652
U17/snR30 is a ubiquitous small nucleolar RNA with two conserved sequence motifs essential for 18S rRNA production.
Mol. Cell. Biol., 24, 1769-1778.
A common sequence motif determines the Cajal body-specific localisation of box H/ACA scaRNAs.
EMBO J., 22, 4283-4293.
Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm.
EMBO J., 22, 1878-1888.
A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains.
Nucleic Acids Res., 30, 4643-4649.
Cajal body-specific small nuclear RNAs: a novel class of 2’-O-methylation and pseudouridylation guide RNAs.
EMBO J., 21, 2746-2756.
Small nucleolar RNAs: An abundant group of noncoding RNAs with diverse cellular functions.
Cell, 109, 145-148.
Analysis of the structure of human telomerase RNA in vivo.
Nucleic Acids Res., 30, 912-920.
A small nucleolar RNA functions both in 2’-O-ribose methylation and pseudouridylation of the U5 spliceosomal RNA.
EMBO J., 20, 541-551.
Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs.
EMBO J., 20, 3617-3622.
7SK snRNA binds to and regulates the activity of cdk9/cyclin T complexes.
Nature, 414, 322-325.
Elements essential for accumulation and function of small nucleolar RNAs directing site-specific pseudouridylation of ribosomal RNAs.
EMBO J., 18, 457-469.
Nucleolar factors direct the 2’-O-methylation and pseudouridylation of U6 spliceosomal RNA.
Mol. Cell. Biol. 19, 6906-6917.
Nucleolar localization signals of box H/ACA small nucleolar RNAs.
EMBO J., 18, 5120-5130.
Sequence and structural elements of methylation guide snoRNAs essential for site-specific ribose methylation of pre-rRNA.
EMBO J., 17, 797-807.
Function and synthesis of small nucleolar RNAs.
Curr. Opinion Cell Biol., 9, 337-342.
A small nucleolar RNP protein is required for pseudouridylation of eukaryotic ribosomal RNAs.
EMBO J., 16, 4770-4776.
Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs.
Cell 89, 799-809.
The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation.
Genes Dev., 11, 941-956.
Site-specific ribose methylation of preribosomal RNA: A novel function for small nucleolar RNAs.
Cell 85, 1077-1088.