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Team publications Legube

Mazzocca M, Loffreda A, Colombo E, Fillot T, Gnani D, Falletta P, Monteleone E, Capozi S, Bertrand E, Legube G, Lavagnino Z, Tacchetti C, Mazza D.
Chromatin organization drives the search mechanism of nuclear factors
Nature Communications
2023 Oct
Arnould C, Rocher V, Saur F, Bader AS, Muzzopappa F, Collins S, Lesage E, Le Bozec B, Puget N, Clouaire T, Mangeat T, Mourad R, Ahituv N, Noordermeer D, Erdel F, Bushell M, Marnef A, Legube G..
Chromatin compartmentalization regulates the response to DNA damage
Nature
2023 Oct
Gritti I, Basso V, Rinchai D, Corigliano F, Pivetti S, Gaviraghi M, Rosano D, Mazza D, Barozzi S, Roncador M, Parmigiani G, Legube G, Parazzoli D, Cittaro D, Bedognetti D, Mondino A, Segalla S, Tonon G.
Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism.
EMBO Journal
2022 Nov
Groelly FJ, Dagg RA, Petropoulos M, Rossetti GG, Prasad B, Panagopoulos A, Paulsen T, Karamichali A, Jones SE, Ochs F, Dionellis VS, Puig Lombardi E, Miossec MJ, Lockstone H, Legube G, Blackford AN, Altmeyer M, Halazonetis TD, Tarsounas M.
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells
Mol Cell
2022 Sep
Cohen S, Guenolé A, Lazar I, Marnef A, Clouaire T, Vernekar DV, Puget N, Rocher V, Arnould C, Aguirrebengoa M, Genais M, Firmin N, Shamanna RA, Mourad R, Bohr VA, Borde V, Legube G..
A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation.
Nature Communication
2022 Apr
Personnaz J, Piccolo E, Dortignac A, Iacovoni JS, Mariette J, Rocher V, Polizzi A, Batut A, Deleruyelle S, Bourdens L, Delos O, Combes-Soia L, Paccoud R, Moreau E, Martins F, Clouaire T, Benhamed F, Montagner A, Wahli W, Schwabe RF, Yart A, Castan-Laurell I, Bertrand-Michel J, Burlet-Schiltz O, Postic C, Denechaud PD, Moro C, Legube G, Lee CH, Guillou H, Valet P, Dray C, Pradère JP..
Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor
Science Advances
2022 Mar
Lesage E, Clouaire T, Legube G..
Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci.
DNA Repair
2021 Aug
Marnef A, Legube G..
R-loops as Janus-faced modulators of DNA repair.
Nat Cell Biol
2021 Apr
Arnould C, Rocher V, Finoux AL, Clouaire T, Li K, Zhou F, Caron P, Mangeot PE, Ricci EP, Mourad R, Haber JE, Noordermeer D, Legube G..
Loop extrusion as a mechanism for formation of DNA damage repair foci.
Nature
2021 Feb
Vítor AC, Huertas P, Legube G, de Almeida SF..
Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox.
Front Mol Biosci.
2020 Feb
Arnould C, Legube G..
The Secret Life of Chromosome Loops upon DNA Double-Strand Break.
J Mol Biol.
2020 Feb
Marnef A, Legube G..
m6A RNA modification as a new player in R-loop regulation.
Nat Genet.
2020 Jan
Aline Marnef, Anne-Laure Finoux, Coline Arnould, Emmanuelle Guillou, Virginie Daburon, Vincent Rocher, Thomas Mangeat, Philippe E. Mangeot, Emiliano P. Ricci and Gaëlle Legube .
A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair
Genes and Development
2019 Aug
Puget N, Miller KM, Legube G.
Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?
DNA repair
2019 Jul
Clouaire T, Legube G.
A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks
Trends in Genetics
2019 May
Mangeot PE, Risson V, Fusil F, Marnef A, Laurent E, Blin J, Mournetas V, Massouridès E, Sohier TJM, Corbin A, Aubé F, Teixeira M, Pinset C, Schaeffer L, Legube G, Cosset FL, Verhoeyen E, Ohlmann T, Ricci EP.
Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins
Nature communications
2019 Jan
He YJ, Meghani K, Caron MC, Yang C, Ronato DA, Bian J, Sharma A, Moore J, Niraj J, Detappe A, Doench JG, Legube G, Root DE, D'Andrea AD, Drané P, De S, Konstantinopoulos PA, Masson JY, Chowdhury D..
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.
Nature
2018 Nov
Clouaire T, Rocher V, Lashgari A, Arnould C, Aguirrebengoa M, Biernacka A, Skrzypczak M, Aymard F, Fongang B, Dojer N, Iacovoni JS, Rowicka M, Ginalski K, Côté J, Legube G.
Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures
Molecular Cell
2018 Oct
Full Publication List

2018 Aug
Mourad R, Ginalski K, Legube G, Cuvier O..
Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution.
Genome Biol
2018 Mar
Cohen S, Puget N, Lin YL, Clouaire T, Aguirrebengoa M, Rocher V, Pasero P, Canitrot Y, Legube G.
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
Nature Communication
2018 Feb
Guénolé A, Legube G..
A meeting at risk: Unrepaired DSBs go for broke.
Nucleus
2017 Nov
Clouaire T, Marnef A, Legube G..
Taming Tricky DSBs: ATM on duty.
DNA repair
2017 Jun
Marnef A, Cohen S, Legube G..
Transcription-coupled DNA Double Strand Break repair: Active genes need special care.
J Mol Biol.
2017 Mar
Aymard F, Aguirrebengoa M, Guillou E, Javierre BM, Bugler B, Arnould C, Rocher V, Iacovoni JS, Biernacka A, Skrzypczak M, Ginalski K, Rowicka M, Fraser P, Legube G..
Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes.
Nat Struct Mol Biol
2017 Mar
Marnef A, Legube G..
Organizing DNA repair in the nucleus: DSBs hit the road.
Curr Opin Cell Biol.
2017 Jan
Caron P, Choudjaye J, Clouaire T, Bugler B, Daburon V, Aguirrebengoa M, Mangeat T, Iacovoni JS, Álvarez-Quilón A, Cortés-Ledesma F, Legube G..
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks.
Cell Reports
2015 Nov .
Clouaire T, Legube G.
DNA double strand break repair pathway choice: a chromatin based decision?
Nucleus.
2015 Feb
Aymard F, Bugler B, Schmidt CK, Guillou E, Caron P, Briois S, Iacovoni JS, Daburon V, Miller KM, Jackson SP, Legube G..
Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
Nat Struct Mol Biol.
2014 Apr
Lee CS, Lee K, Legube G, Haber JE.
Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break
Nat Struct Mol Biol
2014 Jan
Caron P, Aymard F, Iacovoni JS, Briois S, Canitrot Y, Bugler B, Massip L, Losada A, Legube G.
Cohesin protects genes against γH2AX Induced by DNA double-strand breaks
PLoS Genetics
2012 Jan
Iacovoni JS, Caron P, Lassadi I, Nicolas E, Massip L, Trouche D, Legube G.
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome.
EMBO Journal
2010 Apr
Arnould C, Rocher V, Legube G..
Analyzing Homologous Recombination at a Genome-Wide Level.
Methods Mol Biol.

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