Role of cell cycle in cell fate decision

Presentation

Our aim is to understand how the cell cycle affects cell fate decisions in organ development and homeostasis using as a paradigm the developing nervous system. Deciphering the core machinery of cell cycle has been mostly the focus of cell biologists, while, developmental biologists identified the signaling pathways and transcriptional programs controlling cell fate choices. The interplay between these two fundamental aspects of biology remained largely unexplored. The goal of our project is to implement molecular analyses with advanced technique in time-lapse imaging to elucidate how changes in cell cycle features switch a proliferating neural progenitor into a differentiating neuron.

Projets

Publications

• Angie Molina, Frederic Bonnet, Julie Pignolet, Valerie Lobjois, Sophie Bel-vialar, Jacques Gautrais, Fabienne Pituello, Eric Agius.
  Single-cell imaging of the cell cycle reveals CDC25B-induced heterogeneity of G1 phase length in neural progenitor cells
  Development
  2022 Jun
• Bonnet F, Molina A, Roussat M, Azais M, Bel-Vialar S, Gautrais J, Pituello F, Agius E.
  Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase.
  Elife
  2018 Jul
• Lacomme M, Medevielle F, Bourbon HM, Thierion E, Kleinjan DJ, Roussat M, Pituello F, Bel-Vialar S..
  A long range distal enhancer controls temporal fine-tuning of PAX6 expression in neuronal precursors.
  Dev Biol.
  2018 Apr
• Angie Molina, Fabienne Pituello.
  Playing with the cell cycle to build the spinal cord
  Developmental Biology
  2017 Dec review
• 2015 Jan AGIUS, E., BEL-VIALAR, S., BONNET, F., PITUELLO, F. (2015). Cell cycle and cell fate in the developing nervous system: the role of CDC25B phosphatase. Cell Tissue Res 359, 201-13.

View all publications

Funding

Ligue régionale contre le cancer