Role of cell cycle in cell fate decision

Fabienne Pituello

DR CNRS
05 61 55 83 49

Team members

  Researcher
  • Eric Agius
  • Sophie Bel-Vialar
  • Fabienne Pituello
  Associate professor
  • Valerie Lobjois
  Technical staff
  • Francois Médevielle
  • Perrine Uhart
  PhD student
  • Sofiane Omerani
  • Delphine Bretonniere
  • Julie Pignolet

Presentation

Our aim is to understand how the cell cycle affects cell fate decisions in organ development and homeostasis using as a paradigm the developing nervous system. Deciphering the core machinery of cell cycle has been mostly the focus of cell biologists, while, developmental biologists identified the signaling pathways and transcriptional programs controlling cell fate choices. The interplay between these two fundamental aspects of biology remained largely unexplored. The goal of our project is to implement molecular analyses with advanced technique in time-lapse imaging to elucidate how changes in cell cycle features switch a proliferating neural progenitor into a differentiating neuron.

Projets

Function of a cell cycle regulator, the CDC25B phosphatase, in Vertebrate neurogenesis

Role of cell cycle in cell fate decision during organogenesis: Insight into the developing nervous system using single cell high resolution time lapse imaging

The CDC25B phosphatase shortens the G2 phase of neural progenitors and promotes efficient neuron production

The proneural NeuroG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle

Publications

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Institute

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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