Chromatin and cell proliferation

Didier Trouche


DR
05 61 55 62 10

Team members

  Research engineer
  • Catherine Chailleux
  Researcher
  • Yvan Canitrot
  • Fabrice Escaffit
  • Lisa Muniz
  • Estelle Nicolas
  • Didier Trouche
  • Marie Vandromme
  • Valerie Bergoglio
  Associate professor
  • Martine Briet
  • Anne Fernandez Vidal
  Technical staff
  • Aurelien Guillou
  • Céline Reyes
  PhD student
  • Mahdia Abdi Galab
  • Julien Ouvrard
  • Luana Cintori

Presentation

Our team is interested in the role of chromatin modifications and the enzymes that regulate them in the control of mammalian cell proliferation and genetic stability. Our goal is to understand the molecular basis of the establishment of genetic programs associated with cell proliferation or anti-proliferative processes (terminal differentiation, senescence) by chromatin modifiers. We also study the involvement of these enzymes in genetic stability, focusing on DNA damage repair.

For more information, please consult the details of each of the team's projects ...

 

History

The team "Chromatin and Cellular Proliferation" is directed since its creation in 2000 by Dr Didier Trouche.

From 2000 to 2007, it was part of the LBME (Laboratory of Molecular Biology of Eukaryotes, CNRS-UPS UMR 5099).

In January 2007, the team joined the LBCMCP (Laboratory of Cellular and Molecular Biology of Proliferation Control, CNRS-UPS UMR 5088).

From 2011 to 2020, Didier Trouche was the director of the LBCMCP and, from 2016 to 2020, the director of the Center for Integrative Biology (CBI) of Toulouse with Pierre-Emmanuel Gleizes (Director of the LBME) as deputy.

 

Location

The team is now part of the Center for Integrative Biology (CBI, CNRS-UPS FR3743) to which it belongs as a team attached to the Molecular, Cellular and Developmental Biology unit (MCD, CNRS-UPS UMR5077).

The laboratory is located on the campus of the University Toulouse III - Paul Sabatier, and housed in the building 4R4. It is also part of the Federation of Research in Biology of Toulouse (FRBT).

 

Contact

Dr Didier Trouche
Centre for Integrative Biology (CBI) of Toulouse
MCD, CNRS UMR 5077
Université Toulouse III Paul Sabatier - Bât 4R4
118 route de Narbonne
31062 TOULOUSE Cedex
e-mail : didier.trouche@univ-tlse3.fr
Phone : (+33) 5 61 55 62 10
 
 
 
 

Projets

Histone demethylases and cell physiology
(M. Vandromme)

Non coding RNA and senescence
(E. Nicolas)

Transcriptional regulations by the Tip60/p400/H2A.Z complex in the intestinal epithelial physiopathology
(M. Briet & F. Escaffit)

Chromatin and DNA repair
(Y. Canitrot)

Publications

  • Rispal J, Escaffit F, Trouche D.
    Chromatin Dynamics in Intestinal Epithelial Homeostasis: A Paradigm of Cell Fate Determination versus Cell Plasticity
    Stem Cell Reviews and Reports
    2020 Oct doi: 10.1007/s12015-020-10055-0
  • Lamaa A, Humbert J, Aguirrebengoa M, Cheng X, Nicolas E, Côté J, Trouche D..
    Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation.
    Elife
    2020 Feb 28;9. doi: 10.7554/eLife.53375
  • Rispal J, Baron L, Beaulieu J-F, Chevillard-Briet M, Trouche D, Escaffit F.
    The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis.
    Nature Communications
    2019 Apr 10 (1): 1827.
  • Chevillard-Briet M, Escaffit F.
    Methods for In Vivo Functional Studies of Chromatin-Modifying Enzymes in Early Steps of Colon Carcinogenesis.
    In: Colorectal Cancer. Methods in Molecular Biology
    2018 Mar Beaulieu JF (eds) Humana Press, New York, NY 1765:79-85.
  • §Muniz L., §Deb M.K. (§co-first authors), Aguirrebengoa M., Lazorthes S., *Trouche D., *Nicolas E .(*co-last authors).
    Control of gene expression in senescence through transcriptional read-through of convergent protein-coding genes
    Cell Reports
    2017 Nov 21(9):2433-2446.

View all publications

Funding

           

Alumni

Researchers
Teacher-researchers

Post-doctoral fellowsTechnical or administrative staffPhD StudentsStudents (except thesis)
Gaëlle LEGUBELaurent MASSIPSébastien BRIOISSandrine TYTECAJulien DURAND
Virginie CHARASSONAssala LAAMASabine PINELPierre CARONLucie BARON
Marie VANDROMME Muriel QUARANTA-NICAISELise MATERRACécile COIFFAIT
  Marion AGUIRREBENGOALaure VERRIERRémi BOUDOU
   Céline COURILLEAUClémence RIVES
   Kader SALIFOUPaul DUCHESNE
   Sandra LAZORTHESCaroline LEONI
   Maharshi K DEBNatacha PONSOLLE
   Gemael TATY-TATYDjihane ABDESSELAM
   Aude GREZY 
   Jérémie FAGES 
   Jérémie RISPAL 

Institute

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

Annuaire général