Our team is interested in the role and regulation of chromatin modifications and chromatin modifying enzymes in the control of mammalian cell proliferation and in genetic stability. Our aim is to understand the molecular bases of the setting up of specific genetic programs associated with cell proliferation or anti-proliferative processes (terminal differentiation, senescence) by chromatin modifiers. We are also investigating the involvement of these enzymes in genetic stability, focusing on the repair of DNA damages. For more information, please see details of our different projects ...
The « Chromatin and Cell Proliferation » group is managed since its creation in 2000 by Dr Didier Trouche. From 2000 to 2007, it belonged to the LBME (Laboratory of Molecular Biology in Eukaryotes), a laboratory from the CNRS, in Toulouse. In January 2007, the group moved to another CNRS laboratory, the LBCMCP (Laboratory of the Cellular and Molecular Biology of Cell Proliferation Control).
Since 2011, Didier Trouche provides leadership of the LBCMCP and, since 2016, he is the director of the Center for Integrative Biology (CBI) of Toulouse, together with Pierre-Emmanuel Gleizes (director of the LBME) as deputy-director.
The group is located on the University Paul Sabatier Campus in Toulouse (France) and belongs to the Center of Integrative Biology (CBI). It also belongs to the FRBT Institute (Federation of Research in Biology of Toulouse).
Maharshi K DEB