Chromatin and cell proliferation

Didier Trouche


DR
05 61 55 62 10

Team members

  Researcher  Associate professor
  • Martine Briet
  • Virginie Charasson
  Technical staff
  • Catherine Chailleux
  • Solenne Gaillard
  • Aurelien Guillou
  Postdoctoral fellow
  • Assala Mallak
  • Lisa Muniz
  PhD student
  • Jérémie Fages
  • Julien Ouvrard
  • Mahdia Abdi galab
  Master student
  • Maxime Delmas
  • Pauline Sartre
  • Aurore Duquenne
  • Dossi carine Gnide
  • Aurore Duquenne
  • Paul Duschesne
  • Alexandre Larose

Presentation

 

 

Our team is interested in the role and regulation of chromatin modifications and chromatin modifying enzymes in the control of mammalian cell proliferation and in genetic stability. Our aim is to understand the molecular bases of the setting up of specific genetic programs associated with cell proliferation or anti-proliferative processes (terminal differentiation, senescence) by chromatin modifiers. We are also investigating the involvement of these enzymes in genetic stability, focusing on the repair of DNA damages. For more information, please see details of our different projects ...

History

The « Chromatin and Cell Proliferation » group is managed since its creation in 2000 by Dr Didier Trouche. From 2000 to 2007, it belonged to the LBME (Laboratory of Molecular Biology in Eukaryotes), a laboratory from the CNRS, in Toulouse. In January 2007, the group moved to another CNRS laboratory, the LBCMCP (Laboratory of the Cellular and Molecular Biology of Cell Proliferation Control).

Since 2011, Didier Trouche provides leadership of the LBCMCP and, since 2016, he is the director of the Center for Integrative Biology (CBI) of Toulouse, together with Pierre-Emmanuel Gleizes (director of the LBME) as deputy-director.

Location

The group is located on the University Paul Sabatier Campus in Toulouse (France) and belongs to the Center of Integrative Biology (CBI). It also belongs to the FRBT Institute (Federation of Research in Biology of Toulouse).

Contact

Dr Didier Trouche
Center for Integrative Biology (CBI) of Toulouse
LBCMCP, CNRS UMR 5088
Université Paul Sabatier
Bat 4R3B1
118 route de Narbonne
31062 TOULOUSE Cedex
Phone : (+33) 5 61 55 62 10

Projets

Histone demethylases and cell physiology
(M. Vandromme)

Non coding RNA and senescence
(E. Nicolas)

Transcriptional regulations depending on Tip60 complex
(M. Briet & F. Escaffit)

Chromatin and DNA repair
(Y. Canitrot)

Publications

  • Lamaa A, Humbert J, Aguirrebengoa M, Cheng X, Nicolas E, Côté J, Trouche D..
    Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation.
    Elife
    2020 Feb 28;9. doi: 10.7554/eLife.53375
  • Rispal J, Baron L, Beaulieu J-F, Chevillard-Briet M, Trouche D, Escaffit F.
    The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis.
    Nature Communications
    2019 Apr 10 (1): 1827.
  • Chevillard-Briet M, Escaffit F.
    Methods for In Vivo Functional Studies of Chromatin-Modifying Enzymes in Early Steps of Colon Carcinogenesis.
    In: Colorectal Cancer. Methods in Molecular Biology
    2018 Mar Beaulieu JF (eds) Humana Press, New York, NY 1765:79-85.
  • §Muniz L., §Deb M.K. (§co-first authors), Aguirrebengoa M., Lazorthes S., *Trouche D., *Nicolas E .(*co-last authors).
    Control of gene expression in senescence through transcriptional read-through of convergent protein-coding genes
    Cell Reports
    2017 Nov 21(9):2433-2446.
  • Grézy A, Chevillard-Briet M, Trouche D, Escaffit F..
    Control of genetic stability by a new heterochromatin compaction pathway involving the Tip60 histone acetyltransferase.
    Mol Biol Cell.
    2016 Jan 27(4):599-607

View all publications

Funding

             

Alumni

Marion AGUIRREBENGOA

Aude GREZY

Gemael TATY-TATY

Maharshi K DEB

Muriel QUARANTA-NICAISE

Sabine PINEL

Sandra LAZORTHES

Kader SALIFOU

Céline COURILLEAU

Laure VERRIER

Sébastien BRIOIS

Lise MATERRA

Sandrine TYTECA

Institute

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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