Cell migration and cancer

Xiaobo Wang

CR
05 61 55 78 88

Team members

  Researcher
  • Karine Belguise
  • Xiaobo Wang
  Technical staff
  • Aurelien Guillou
  PhD student
  • Sijia Zhou
  • Hao Li
  • Ye Zhang

Thèmes de recherche

    Presentation

    Cell migration is critically important in both physiological and pathological processes. Aberration of cell migration can cause a variety of problems including birth defect, immune problem, and cancer metastasis. Cell migration is generally classified into two principle types, individual and collective cell migration. Compared with the well characterized individual cell migration, collective cell migration still remains poorly understood. The main objective of our team is to better understand the controlling mechanism of these different types of migration. In this purpose, we are using different models (Drosophila, cancer cells, mouse) combined with new biotechniques (optogenetic, FRET, caged system)and ex vivo/in vitro live cell imaging.

    Projets

    Actomyosin oscillation of collective cells

    Intercellular communication during collective cell migration

    Control of cancer invasion by the novel PKCtheta

    Controlling mechanism of rotational movement during collective cell migration

    Publications

    • Chadelle L, Liu J, Choesmel-Cadamuro V, Karginov AV, Froment C, Burlet-Schiltz O, Gandarillas S, Barreira Y, Segura C, Van Den Berghe L, Czaplicki G, Van Acker N, Dalenc F, Franchet C, Hahn KM, Wang X, Belguise K..
      PKCθ-mediated serine/threonine phosphorylations of FAK govern adhesion and protrusion dynamics within the lamellipodia of migrating breast cancer cells.
      Cancer Letters
      2021 Nov 2021 Nov 23;526:112-130. doi: 10.1016/j.canlet.2021.11.026. Online ahead of print.
    • Wang H, Guo X, Wang X, Wang X, Chen J..
      Supracellular Actomyosin Mediates Cell-Cell Communication and Shapes Collective Migratory Morphology
      iScience
      2020 Jun 23(6):101204. doi: 10.1016/j.isci.2020.101204
    • Chen Y, Kotian N, Aranjuez G, Chen L, Messer CL, Burtscher A, Sawant K, Ramel D, Wang X, McDonald JA..
      Protein phosphatase 1 activity controls a balance between collective and single cell modes of migration.
      Elife
      2020 May 9:e52979. doi: 10.7554/eLife.52979.
    • Popkova A, Stone OJ, Chen L, Qin X, Liu C, Liu J, Belguise K, Montell DJ, Hahn KM, Rauzi M, Wang X..
      A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension
      Nat Commun
      2020 Apr 11(1):1921. doi: 10.1038/s41467-020-15593-2.
    • Wang H, Qiu Z, Xu Z, Chen SJ, Luo J, Wang X, Chen J..
      aPKC is a key polarity determinant in coordinating the function of three distinct cell polarities during collective migration.
      Development.
      2018 May 145(9). pii: dev158444.

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    Institute

    Université Paul Sabatier
    118 Route de Narbonne

    31062 TOULOUSE Cedex
    France

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