Cell migration and cancer
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Technical staff PhD student
- Karine Belguise
- Xiaobo Wang
- Amandine Nicolle
- Sijia Zhou
Cell migration is critically important in both physiological and pathological processes. Aberration of cell migration can cause a variety of problems including birth defect, immune problem, and cancer metastasis. Cell migration is generally classified into two principle types, individual and collective cell migration. Compared with the well characterized individual cell migration, collective cell migration still remains poorly understood. The main objective of our team is to better understand the controlling mechanism of these different types of migration. In this purpose, we are using different models (Drosophila, cancer cells, mouse) combined with new biotechniques (optogenetic, FRET, caged system)and ex vivo/in vitro live cell imaging.
Actomyosin oscillation of collective cells
Intercellular communication during collective cell migration
Control of cancer invasion by the novel PKCtheta
Controlling mechanism of rotational movement during collective cell migration
- Wang H, Qiu Z, Xu Z, Chen SJ, Luo J, Wang X, Chen J..
aPKC is a key polarity determinant in coordinating the function of three distinct cell polarities during collective migration.
2018 May 145(9). pii: dev158444.
- Qin X, Hannezo E, Mangeat T, Liu C, Majumder P, Liu J, Choesmel-Cadamuro V, McDonald JA, Liu Y, Yi B, Wang X..
A biochemical network controlling basal myosin oscillation.
2018 Mar 9(1):1210.
- Qin X, Park BO, Liu J, Chen B, Choesmel-Cadamuro V, Belguise K, Heo WD, Wang X..
Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation.
2017 Apr 8:14708
- Colombié N, Choesmel-Cadamuro V, Series J, Emery G, Wang X, Ramel D..
Non-autonomous role of Cdc42 in cell-cell communication during collective migration.
2017 Mar 423(1):12-18.
- Combedazou A, Choesmel-Cadamuro V, Gay G, Liu J, Dupré L, Ramel D, Wang X..
Myosin II governs collective cell migration behaviour downstream of guidance receptor signalling.
J Cell Sci.
2017 Jan 130(1):97-103.
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