Controlling mechanism of rotational movement during collective cell migration


  • Xiaobo Wang
  • Karine Belguise
  • Hao Li
  • Bing Liu
  • Kevin Mouysset
  • Ye Zhang
  • Sijia Zhou
  • Aurelien Guillou

Currently, chemotaxis is a major concept to explain the polarity of collectively migratory cell group and thus the choice and difference of leader cells from other cells. However, this concept of chemotaxis-deciding leader cell can’t explain an interesting observation from both collective border cell migration in Drosophila ovary and collective cancer cell migration in wound healing assay: cells can change their relative position and thus leaders can be replaced by others, through rotation or tumbling movement. Here, we are trying to elucidate the controlling mechanism of this rotation behavior using both ex vivo drosophila and in vitro cell models. 


Other funding : ATIP-Avenir


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