Coordinators : Gaelle Legube, Philippe Rousseau
The CODE (Chromosome Organization Dynamics and Evolution) research program aims at unravelling the mechanisms and functions involved in genome maintenance, expression and evolution. Stable maintenance of the genetic information requires an accurate global organization within cells and nuclei and the activity of numerous molecular machines acting in replication, repair and segregation that are finely controlled in space and time. In parallel, rapid and accurate regulation of gene expression in response to environmental cues or during differentiation is based on complex and robust genetic programs that necessitate accurate spatial and temporal coordination.
The CODE research program of the CBI gathers 13 teams that tackle the questions of genome expression, maintenance and evolution. In particular, they seek to understand the role of chromatin and chromosome structure in transcription, repair, and chromosome segregation using a large number of model systems ranging from bacteria to mouse, and the most up to date technologies including biochemistry and biophysics of single molecules, molecular genetics, in vivo and in vitro imaging at different scales, computational biology and genome-wide approaches.