Petra Langendijk-genevaux

Presentation

As a biological data processing scientific engineer in bioinformatics, I conduct comparative genomic analyses with phylogenomic approaches. Our team's main research interest is to use genomic data to clarify the evolutionary history (ancestral genes, horizontal gene transfers, gene gains/losses) that shaped key cellular processes. I also provide functional information on genes for experimental work. My favorite model organisms are archaea and bacteria, but I also study some eucaryotes, including humans.

I work in the team Genomics of integrated systems (Fichant) where I manage and maintain the databases for complete genomes of bacteria and archaea, like the Archaeal and Bacterial ABC systems database, ABCdb. I participate in a research project, ANR CASPAR, in collaboration with the team RNA biology in Archaea (Clouet-d'Orval). In this project I perform the phylogenomic analysis of helicases among the archaea.

I maintain the LMGM website together with its group of team referents.

References Pubmed - Citations google scholar - Orcid - ResearcherID - Research gate - LinkedIn - Thesis

Recent publication :

• Hajj M*, Langendijk-Genevaux P*, Batista M, Quentin Y, Laurent S, Capeyrou R, Abdel-Razzak Z, Flament D, Chamieh H, Fichant G, Clouet-d'Orval B, Bouvier M. Phylogenetic Diversity of Lhr Proteins and Biochemical Activities of the Thermococcales aLhr2 DNA/RNA Helicase. Biomolecules. 2021 Jun 26;11(7):950. doi: 10.3390/biom11070950. PMID: 34206878. *co-first authors

Publications

• D.K. Phung, C. Etienne, M. Batista, P. Langendijk-Genevaux, Y. Moalic, S. Laurent, S. Liuu, V. Morales, M. Jebbar, G. Fichant, M. Bouvier, D. Flament, B. Clouet-d’Orval.
  RNA processing machineries in Archaea: the 5′-3′ exoribonuclease aRNase J of the β-CASP family is engaged specifically with the helicase ASH-Ski2 and the 3′-5′ exoribonucleolytic RNA exosome machinery
  Nucleic Acids Research
  2020 Feb
• Manon Batista1, Petra Langendijk-Genevaux1, Mirna Hajj1,Duy Khanh Phung2, Laura Plassart3, Marie Bouvier1, Gwennaële Fichant1, and Béatrice Clouet-d’Orval1*.
  The Archaeal Specific Helicase of the Ski2-like family, ASH-Ski2, is an authentic RNA helicase
  2019 Dec en préparation
• Hinz U; UniProt Consortium (incl Langendijk-Genevaux PS)..
  From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.
  Cell Mol Life Sci.
  2010 Apr 67(7):1049-1064. doi:10.1007/s00018-009-0229-6
• UniProt Consortium..
  The Universal Protein Resource (UniProt) in 2010.
  Nucleic Acids Res.
  2010 Jan 38(Database issue):D142-D148. doi:10.1093/nar/gkp846
• Sigrist CJ, Cerutti L, de Castro E, Langendijk-Genevaux PS, Bulliard V, Bairoch A, Hulo N..
  PROSITE, a protein domain database for functional characterization and annotation.
  Nucleic Acids Res.
  2010 Jan 38(Database issue):D161-6. doi: 10.1093/nar/gkp885

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