Presentation
As a biological data processing scientific engineer in bioinformatics, I conduct comparative genomic analyses with phylogenomic approaches. Our team's main research interest is to use genomic data to clarify the evolutionary history (ancestral genes, horizontal gene transfers, gene gains/losses) that shaped key cellular processes. I also provide functional information on genes for experimental work. My favorite model organisms are archaea and bacteria, but I also study eucaryal species, including humans.
I work in the team Genomics of integrated systems (Fichant) where I manage and maintain the databases for complete genomes of bacteria and archaea, like the Archaeal and Bacterial ABC systems database, ABCdb. I perform the phylogenomic analysis of helicases implicated in the RNA metabolism among the archaea, in a research project in 
collaboration with the team RNA biology in Archaea (Clouet-d'Orval). In collaboration with P. Redder's team I also study helicases implicated in the RNA metabolism of the pathogen Staphylococcus aureus and other Bacillota.
I maintain the LMGM website together with its group of team referents.
In CBI 1point5 - Mobility, I co-organize the CBI's shared bicycles, Allons-y à vélo and Digital Cleanup Day.
References Pubmed - Citations google scholar - Orcid - ResearcherID - Research gate - LinkedIn - Thesis
Recent publications :
- Manon Batista † , Petra Langendijk-Genevaux † , Marta Kwapisz, Isabelle Canal, Duy Khanh Phung, Laura Plassart, Régine Capeyrou, Yann Moalic, Mohamed Jebbar, Didier Flament, Gwennaele Fichant, Marie Bouvier and Béatrice Clouet-d’Orval. Evolutionary and functional insights into the Ski2-like helicase family in Archaea: a comparison of Thermococcales ASH-Ski2 and Hel308 activities. NAR Genomics and Bioinformatics. 2024 024 Mar 18;6(1):lqae026. doi: 10.1093/nargab/lqae026. PMID: 38500564. † co-first authors.
- Hajj M*, Langendijk-Genevaux P*, Batista M, Quentin Y, Laurent S, Capeyrou R, Abdel-Razzak Z, Flament D, Chamieh H, Fichant G, Clouet-d'Orval B, Bouvier M. Phylogenetic Diversity of Lhr Proteins and Biochemical Activities of the Thermococcales aLhr2 DNA/RNA Helicase. Biomolecules. 2021 Jun 26;11(7):950. doi: 10.3390/biom11070950. PMID: 34206878. *co-first authors
Publications
- D.K. Phung, C. Etienne, M. Batista, P. Langendijk-Genevaux, Y. Moalic, S. Laurent, S. Liuu, V. Morales, M. Jebbar, G. Fichant, M. Bouvier, D. Flament, B. Clouet-d’Orval.
RNA processing machineries in Archaea: the 5′-3′ exoribonuclease aRNase J of the β-CASP family is engaged specifically with the helicase ASH-Ski2 and the 3′-5′ exoribonucleolytic RNA exosome machinery
Nucleic Acids Research
2020 Feb - Manon Batista1, Petra Langendijk-Genevaux1, Mirna Hajj1,Duy Khanh Phung2, Laura Plassart3, Marie Bouvier1, Gwennaële Fichant1, and Béatrice Clouet-d’Orval1*.
The Archaeal Specific Helicase of the Ski2-like family, ASH-Ski2, is an authentic RNA helicase
2019 Dec en préparation - Hinz U; UniProt Consortium (incl Langendijk-Genevaux PS)..
From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.
Cell Mol Life Sci.
2010 Apr 67(7):1049-1064. doi:10.1007/s00018-009-0229-6 - UniProt Consortium..
The Universal Protein Resource (UniProt) in 2010.
Nucleic Acids Res.
2010 Jan 38(Database issue):D142-D148. doi:10.1093/nar/gkp846 - Sigrist CJ, Cerutti L, de Castro E, Langendijk-Genevaux PS, Bulliard V, Bairoch A, Hulo N..
PROSITE, a protein domain database for functional characterization and annotation.
Nucleic Acids Res.
2010 Jan 38(Database issue):D161-6. doi: 10.1093/nar/gkp885
View all publications
