Mitochondria, adult neurogenesis & learning and memory (MITOGATE)

Intervenants

  • Pascale Belenguer

PI. MC Miquel

This project addresses the little explored question of the involvement of the mitochondrial system in the generation and maintenance of adult neurons in neurodegenerative pathologies. With the Remember team (Richetin et al., 2015), we have highlighted the crucial role of mitochondria in the restoration of synaptic connections of new adult hippocampal neurons in the context of Alzheimer's disease.

Now, using the mouse mitochondrial defect reference model, DOA (due to OPA1 deficiency), we seek to establish the causal role of mitochondrial functions in these properties, through the combined use of behavioural approaches and histological, molecular and viral techniques.

More generally, we intend to show that the defects of plasticity of the adult brain can be compensated, from a completely innovative angle centred on a key organelle: the mitochondria.

 

Collaborators: Claire Rampon, Lionel Mouledous, Stéphane Pech, Camille Lejards (CRCA), Kevin Richetin (CHUV, Lausanne)

 

 

Publications:

  • Richetin K, Moulis M, Millet A, Arràzola MS, Andraini T, Hua J, Davezac  N, Roybon L, Belenguer P, Miquel, MC, Rampon C. (2017) Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease. Neurobiol Dis. Jun;102:113-124.
  • Bertholet AM, Delerue T, Millet AM, Moulis MF, David C, Daloyau M, Arnauné-Pelloquin L, Davezac N, Mils V, Miquel MC, Rojo M, Belenguer P. (2016) Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity. Neurobiol Dis. 90:3-19. 
  • Bertholet AM, Millet A, Guillermin O, Daloyau M., Davezac N., Miquel MC, Belenguer P. (2013)  OPA1 loss of function affects in vitro neuronal maturation BRAIN. 136: 1518-33.

Funding

     

Institute

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

Annuaire général