Presentation
I have recently obtained the FRM grant "amorçage jeunes équipes" and established my research team at the CBI in the summer of 2023. The main goal of my research programme is to understand how and why gene dosage compensation evolved, using the mouse X chromosome as a model, and to decipher molecular mechanisms that allow gene dosage to be sensed and decoded into developmental decisions.
You can find more about me in: Google Scholar | Twitter | LinkedIN
Some of my previous work:
Galupa et al. (2023) Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development
Galupa*, Picard* et al. (2022) Inversion of a topological domain leads to restricted changes in its gene expression and affects interdomain communication
Galupa et al. (2020) A conserved noncoding locus regulates random monoallelic
Xist expression across a topological boundary
Publications
- Galupa R#, Alvarez-Canales G*, Borst NO*, Fuqua T*, Gandara L*, Misunou N*, Richter K*, Alvez MRP, Karumbi E, Perkins ML, Kocijan T, Rushlow CA and Crocker J#..
Enhancer architecture and chromatin accessibility constrain phenotypical space during development
Developmental Cell
2023 Jan #Corresponding authors - Gandara L*, Tsai A*, Ekelöf M, Galupa R, Noon EPB, Alexandrov T and Crocker J.
Developmental phenomics suggests that H3K4 monomethylation catalyzed by Trr functions as a phenotypic capacitor
Cell Reports
2022 Dec - Hauth A, Galupa R, Servant N, Villacorta L, Hauschulz K, van Bemmel JG, Loda A and Heard E.
Deciphering high-resolution 3D chromatin organization via Capture Hi-C
JoVE
2022 Oct - Galupa R*#, Picard C*, Servant N, Nora EP, Zhan Y, van Bemmel JG, Zhan Y, El Marjou F, Johanneau C, Borensztein M, Ancelin K, Giorgetti L and Heard E#.
Inversion of a topological domain leads to restricted changes in its gene expression and affects inter-domain communication
Development
2022 May *Equal contribution, #Corresponding authors
