Regulation of ribosomal RNA synthesis by RNA polymerase I


  • Olivier Gadal
  • Frederic Beckouet
  • Dorian Abenaqui
  • Chaima Azouzi
  • Nathalie Bastie
  • Claudie Carron
  • Christophe Dez
  • Valdir Gomes Neto
  • Isabelle Leger-Silvestre
  • Henri Mboumba
  • Monica Pena Luna
  • Sophie Queille
  • Thomas Verin-Debant

In yeast, we aim at characterizing how ribosomal RNA synthesis is regulated. We isolated RNA polymerase I mutants which are deregulated in rRNA production and processing. We use a combination of RNA biochemistry, structural analysis and genomic approachs to characterize rRNA production in vivo.




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