Persons in charge
Genome biology aims at unravelling the mechanisms and functions involved in genome maintenance and expression. Stable maintenance of the genetic information requires an accurate global organization within cells and nuclei and the activity of numerous molecular machines acting in replication, repair and segregation that need to be finely controlled in space and time. In parallel, rapid and accurate regulation of gene expression in response to environmental events or during differentiation is based on complex and robust genetic programs that necessitate accurate spatial and temporal coordination of synthesis, folding, modification and degradation of the various RNAs and proteins produced by gene expression.
The Genome Dynamics axis of the CBI regroups teams that tackle the questions of genome expression, maintenance and evolution using a large number of model systems ranging from bacteria to mouse, and the most up to date technologies including biochemistry and biophysics of single molecules, molecular genetics, in vivo and in vitro imaging at the different scales and genome-wide approaches.
In particular the axis develop strong research projects on
- RNA biology, particularly non-coding RNA (ncRNA) and Ribonucleoparticules (RNP) regulation and function, as well as the mechanisms involved in RNA metabolism.
- Molecular machines involved in DNA, RNA and proteins metabolism
- Genome transactions involved in genome maintenance and evolution
- Chromosome organization and dynamics
- Chromatin dynamics in response to modifications of the intracellular or extracellular environments and its function in cell fate
- Gene networks, particularly the establishment and plasticity of genetic programs during development and adaptation in both physiological and pathological conditions.