Like a snap hook on a rope, cohesion is an obstacle to the expansion of DNA loops.

The three-dimensional organisation of genomes is crucial to the regulation of various biological processes.

Cohesin, the 'snap hook' of DNA, is essential to this organisation and has two functions: the cohesion of sister chromatids and the formation of loops organising the genome.

Nathalie Bastié, Henri Mboumba, Olivier Gadal, Frédéric Beckouët (MCD-CBI) and their collaborators show how these two functions are complementary, opening the way to new mechanisms for regulating gene expression.


© Nathalie Bastié

Figure : Illustration de l’effet inhibiteur de la cohésion sur l’expansion des boucles d’ADN

© Romain Koszul


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Frédéric Beckouët